Journal ArticleDOI
Natural variability and correlations in the metabolic profile of healthy Eisenia fetida earthworms observed using 1H NMR metabolomics
Melissa L. Whitfield Åslund,Magda A. Celejewski,Brian P. Lankadurai,André J. Simpson,Myrna J. Simpson +4 more
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TLDR
The baseline metabolic profile of healthy, mature earthworms of the species, Eisenia fetida, is sought to better characterize and strong positive correlations were detected between the levels of maltose, betaine, glycine, and glutamate as well as between the Levels of lactate, valine, leucine, alanine, lysine, tyrosine and phenylalanine which had not been reported.About:
This article is published in Chemosphere.The article was published on 2011-05-01. It has received 30 citations till now. The article focuses on the topics: Eisenia fetida & Metabolomics.read more
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Environmental metabolomics: an emerging approach to study organism responses to environmental stressors
TL;DR: Using a wide variety of model organisms, metabolomic studies have detected stress from abiotic factors such as xenobiotic exposure and temperature shifts as well as biotic stressors such as herbivory and competition.
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Metabolomic signatures of increases in temperature and ocean acidification from the reef-building coral, Pocillopora damicornis
TL;DR: A multivariate biomarker approach is presented to assess climate change impacts and advance the mechanistic understanding of stress response in this keystone species.
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NMR-based metabolomic analysis of Haliotis diversicolor exposed to thermal and hypoxic stresses.
TL;DR: (1)H NMR spectroscopy together with pattern recognition methods was used to investigate the responses of muscle and gill of H. diversicolor to thermal and hypoxic stresses and shed some lights on the metabolic influences of environmental stresses on marine organisms.
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In-Vivo NMR Spectroscopy: A Powerful and Complimentary Tool for Understanding Environmental Toxicity
TL;DR: When multidimensional NMR is combined with isotopic labelling, a wide range of metabolites can be identified in-vivo providing a unique window into the living metabolome that is highly complementary to more traditional metabolomics studies employing extracts, tissues, or biofluids.
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1H NMR-based metabolomics of time-dependent responses of Eisenia fetida to sub-lethal phenanthrene exposure.
TL;DR: NMR-based metabolomics is a powerful tool for elucidating time-dependent relationships in addition to the mode of toxicity of phenanthrene in earthworm exposure studies.
References
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Probabilistic Quotient Normalization as Robust Method to Account for Dilution of Complex Biological Mixtures. Application in 1H NMR Metabonomics
TL;DR: The probabilistic quotient normalization is introduced in this work, which is based on the calculation of a most probable dilution factor by looking at the distribution of the quotients of the amplitudes of a test spectrum by those of a reference spectrum.
Book
Principles of biochemistry
TL;DR: The principles of biochemistry as discussed by the authors, a.k.a. Principles of Biochemistry (PBI), were used in the development of the biochemistry of the human body.
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Metabolic Profiling Allows Comprehensive Phenotyping of Genetically or Environmentally Modified Plant Systems
Ute Roessner,Alexander Luedemann,Doreen Brust,Oliver Fiehn,Thomas Linke,Lothar Willmitzer,Alisdair R. Fernie +6 more
TL;DR: The use of metabolic profiling in conjunction with datamining tools as a technique for the comprehensive characterization of a plant genotype is demonstrated.
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Betaine in human nutrition
TL;DR: The growing body of evidence shows that betaine is an important nutrient for the prevention of chronic disease and has been shown to protect internal organs, improve vascular risk factors, and enhance performance.
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Statistical strategies for avoiding false discoveries in metabolomics and related experiments
David Broadhurst,Douglas B. Kell +1 more
TL;DR: A list of some of the simpler checks that might improve one’s confidence that a candidate biomarker is not simply a statistical artefact is provided, and a series of preferred tests and visualisation tools that can assist readers and authors in assessing papers are suggested.