Journal ArticleDOI
Nature of the Scrapie Agent: Self-replication and Scrapie
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This article is published in Nature.The article was published on 1967-09-02. It has received 1049 citations till now. The article focuses on the topics: Scrapie.read more
Citations
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Novel proteinaceous infectious particles cause scrapie
TL;DR: A new term "prion" is proposed to denote a small proteinaceous infectious particle which is resistant to inactivation by most procedures that modify nucleic acids.
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Central Dogma of Molecular Biology
TL;DR: The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information and states that such information cannot be transferred from protein to either protein or nucleic acid.
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Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
TL;DR: It is proposed that this step is mechanistically relevant to amyloid formation in human prion disease and in AD; it is the formation of an ordered nucleus, which is the defining characteristic of a nucleation-dependent polymerization.
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Molecular biology of prion diseases
TL;DR: Understanding prion diseases may advance investigations of other neurodegenerative disorders and of the processes by which neurons differentiate, function for decades, and then grow senescent.
References
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Teleonomic mechanisms in cellular metabolism, growth, and differentiation.
Jacques Monod,François Jacob +1 more
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The exceptionally small size of the scrapie agent
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Scrapie produced experimentally in goats with special reference to the clinical syndrome.
I.H. Pattison,G.C. Millson +1 more
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The possible nature of the transmissible agent of scrapie.
IH Pattison,KM Jones +1 more
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Experimental Scrapie in the Mouse
TL;DR: The disease was transmissible, using a variety of routes in mice, and cases of scrapie developed in goats inoculated with the mouse material, which was filterable, has a high resistance to heat and was demonstrated in the brain and in other tissues.