Nobel Lecture: Prions
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This article is published in Proceedings of the National Academy of Sciences of the United States of America.The article was published on 1998-11-10 and is currently open access. It has received 4643 citations till now.read more
Citations
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The amyloid state and its association with protein misfolding diseases
TL;DR: The ability to form the amyloid state is more general than previously imagined, and its study can provide unique insights into the nature of the functional forms of peptides and proteins, as well as understanding the means by which protein homeostasis can be maintained and protein metastasis avoided.
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Transmission and spreading of tauopathy in transgenic mouse brain
Florence Clavaguera,Tristan Bolmont,R. Anthony Crowther,Dorothee Abramowski,Stephan Frank,Alphonse Probst,Graham Fraser,Anna K. Stalder,Martin Beibel,Matthias Staufenbiel,Mathias Jucker,Michel Goedert,Markus Tolnay +12 more
TL;DR: Transgenic mice expressing mutant (for example, P301S) human tau in nerve cells show the essential features of tauopathies, including neurodegeneration and abundant filaments made of hyperphosphorylated tau protein.
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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
TL;DR: The cellular prion protein (PrPC) is identified as an amyloid-β-oligomer receptor by expression cloning, and PrPC-specific pharmaceuticals may have therapeutic potential for Alzheimer’s disease.
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Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
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Plasma medicine: an introductory review
Michael G. Kong,Gmw Gerrit Kroesen,Gregor E. Morfill,Tetyana Nosenko,Tetsuji Shimizu,van J Jan Dijk,Julia L. Zimmermann +6 more
TL;DR: This introductory review on plasma health care is intended to provide the interested reader with a summary of the current status of this emerging field, its scope, and its broad interdisciplinary approach, ranging from plasma physics, chemistry and technology, to microbiology, biochemistry, biophysics, medicine and hygiene.
References
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Principles that Govern the Folding of Protein Chains
TL;DR: Anfinsen as discussed by the authors provided a sketch of the rich history of research that provided the foundation for his work on protein folding and the Thermodynamic Hypothesis, and outlined potential avenues of current and future scientific exploration.
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Novel proteinaceous infectious particles cause scrapie
TL;DR: A new term "prion" is proposed to denote a small proteinaceous infectious particle which is resistant to inactivation by most procedures that modify nucleic acids.
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Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III
TL;DR: A reprint of Avery, MacLeod, and McCarty's article on the 35th anniversary of its original publication.
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A new variant of Creutzfeldt-Jakob disease in the UK
Robert G. Will,James W. Ironside,M. Zeidler,Simon Cousens,K Estibeiro,Annick Alpérovitch,Sigrid Poser,Maurizio Pocchiari,Albert Hofman,Pete Smith +9 more
TL;DR: Ten cases of Creutzfeldt-Jakob disease have been identified in the UK in recent months with a new neuropathological profile that raises the possibility that they are causally linked to BSE.
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Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
Keh-Ming Pan,Michael J. Baldwin,J Nguyen,María Gasset,Ana Serban,Darlene Groth,Ingrid Mehlhorn,Ziwei Huang,Robert J. Fletterick,Fred E. Cohen +9 more
TL;DR: It is argued that the conversion of alpha-helices into beta-sheets underlies the formation of PrPSc, and it is likely that this conformational transition is a fundamental event in the propagation of prions.