Journal ArticleDOI
Near-infrared spectroscopy: exposing the dark (venous) side of the circulation.
John P. Scott,George M. Hoffman +1 more
TLDR
Near‐infrared spectroscopy provides noninvasive continuous access to the venous side of regional circulations that can approximate organ‐specific and global measures to facilitate the detection of circulatory abnormalities and drive goal‐directed interventions to reduce end‐organ ischemic injury.Abstract:
The safety of anesthesia has improved greatly in the past three decades. Standard perioperative monitoring, including pulse oximetry, has practically eliminated unrecognized arterial hypoxia as a cause for perioperative injury. However, most anesthesia-related cardiac arrests in children are now cardiovascular in origin, and standard monitoring is unable to detect many circulatory abnormalities. Near-infrared spectroscopy provides noninvasive continuous access to the venous side of regional circulations that can approximate organ-specific and global measures to facilitate the detection of circulatory abnormalities and drive goal-directed interventions to reduce end-organ ischemic injury.read more
Citations
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Journal ArticleDOI
Postoperative Cerebral and Somatic Near-Infrared Spectroscopy Saturations and Outcome in Hypoplastic Left Heart Syndrome
George M. Hoffman,George M. Hoffman,Nancy S. Ghanayem,John P. Scott,John P. Scott,James S. Tweddell,Michael E. Mitchell,Michael E. Mitchell,Kathleen A. Mussatto +8 more
TL;DR: Test the hypothesis that near-infrared spectroscopy (NIRS)-derived cerebral and somatic/renal regional saturations can predict survival by analyzing relationships between standard hemodynamic measures, direct and NIRS measures of saturation, and outcome.
Journal ArticleDOI
Cerebral Oxygenation During Pediatric Cardiac Surgery Using Deep Hypothermia Circulatory Arrest
TL;DR: Brain oxygenation changed at distinct points during surgery in all ages, reflecting fundamental cerebral responses to hypothermic CPB, ischemia, and reperfusion, consistent with experimental work in animals.
Journal ArticleDOI
Sevoflurane anesthesia and brain perfusion
O. Rhondali,Agnès Pouyau,Aurélie Mahr,Simon Juhel,Mathilde De Queiroz,Khalid Rhzioual-Berrada,Sylvain Mathews,Dominique Chassard +7 more
TL;DR: To assess the impact of sevoflurane and anesthesia‐induced hypotension on brain perfusion in children younger than 6 months, a large number of patients were referred to the neonatal intensive care unit.
Journal ArticleDOI
An International, Multicenter, Observational Study of Cerebral Oxygenation during Infant and Neonatal Anesthesia
Vanessa A. Olbrecht,Justin Skowno,Vanessa Marchesini,Lili Ding,Yifei Jiang,Christopher G. Ward,Gaofeng Yu,Huacheng Liu,Bernadette Schurink,Laszlo Vutskits,Jurgen C. de Graaff,Francis X. McGowan,Britta S. von Ungern-Sternberg,C D Kurth,Andrew Davidson +14 more
TL;DR: Mild and moderate low cerebral oxygenation occurred frequently, whereas severe low cerebral saturation was uncommon, and low mean arterial pressure was common and not well associated withLow cerebral saturation.
Journal ArticleDOI
Impact of sevoflurane anesthesia on brain oxygenation in children younger than 2 years.
O. Rhondali,Simon Juhel,Sylvain Mathews,Quentin Cellier,François-Pierrick Desgranges,Aurélie Mahr,Mathilde De Queiroz,Agnès Pouyau,Khalid Rhzioual-Berrada,Dominique Chassard +9 more
TL;DR: To assess the impact of sevoflurane and anesthesia‐induced hypotension on brain oxygenation in children younger than 2 years, a large number of patients were referred to the neonatal intensive care unit.
References
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Journal ArticleDOI
Benefit of neurophysiologic monitoring for pediatric cardiac surgery
Erle H. Austin,Harvey L. Edmonds,Steven M. Auden,Vedad Seremet,Greg Niznik,Aida Sehic,Michael K. Sowell,Caryn D. Cheppo,Karen M. Corlett +8 more
TL;DR: Interventions based on neurophysiologic monitoring appear to decrease the incidence of postoperative neurologic sequelae and reduce the length of stay, and both patients and hospital may profit from this service.
Journal ArticleDOI
Intraoperative Hypotension and 1-Year Mortality after Noncardiac Surgery
Jilles B. Bijker,Wilton A. van Klei,Yvonne Vergouwe,Douglas J. Eleveld,Leo van Wolfswinkel,Karel G.M. Moons,Cor J. Kalkman +6 more
TL;DR: This observational study showed no causal relation between IOH and 1-yr mortality after noncardiac surgery for any of the definitions of IOH, but additional analysis suggested that for elderly patients, the mortality risk increases when the duration of I OH becomes long enough, suggesting that lower blood pressures are tolerated for shorter durations.
Journal ArticleDOI
Adventures in the Pathophysiology of Brain Ischemia: Penumbra, Gene Expression, Neuroprotection The 2002 Thomas Willis Lecture
TL;DR: Insight into the ischemic penumbra enabled by a multimodal experimental approach is highlighted; gene expression in ischemia is discussed; and the challenges of neuroprotectant therapy are confronted.
Journal ArticleDOI
Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion
Catherine L. Dent,James P. Spaeth,Blaise V. Jones,Steven M. Schwartz,Tracy A. Glauser,Barbara Hallinan,Jeffrey M. Pearl,Philip R. Khoury,C. Dean Kurth +8 more
TL;DR: Despite the adoption of regional cerebral perfusion, postoperative cerebral ischemic lesions are frequent, occurring in the majority of infants after the Norwood operation, and long-term follow-up is necessary to assess the functional effect of these lesions.
Journal ArticleDOI
Trends in anesthesia-related death and brain damage: A closed claims analysis.
TL;DR: A significant decrease in the proportion of claims for death or permanent brain damage from 1975 through 2000 seems to be unrelated to a marked increase in theportion of claims where pulse oximetry and end-tidal carbon dioxide monitoring were used.
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