Journal ArticleDOI
Near-infrared spectroscopy: exposing the dark (venous) side of the circulation.
John P. Scott,George M. Hoffman +1 more
TLDR
Near‐infrared spectroscopy provides noninvasive continuous access to the venous side of regional circulations that can approximate organ‐specific and global measures to facilitate the detection of circulatory abnormalities and drive goal‐directed interventions to reduce end‐organ ischemic injury.Abstract:
The safety of anesthesia has improved greatly in the past three decades. Standard perioperative monitoring, including pulse oximetry, has practically eliminated unrecognized arterial hypoxia as a cause for perioperative injury. However, most anesthesia-related cardiac arrests in children are now cardiovascular in origin, and standard monitoring is unable to detect many circulatory abnormalities. Near-infrared spectroscopy provides noninvasive continuous access to the venous side of regional circulations that can approximate organ-specific and global measures to facilitate the detection of circulatory abnormalities and drive goal-directed interventions to reduce end-organ ischemic injury.read more
Citations
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Journal ArticleDOI
Postoperative Cerebral and Somatic Near-Infrared Spectroscopy Saturations and Outcome in Hypoplastic Left Heart Syndrome
George M. Hoffman,George M. Hoffman,Nancy S. Ghanayem,John P. Scott,John P. Scott,James S. Tweddell,Michael E. Mitchell,Michael E. Mitchell,Kathleen A. Mussatto +8 more
TL;DR: Test the hypothesis that near-infrared spectroscopy (NIRS)-derived cerebral and somatic/renal regional saturations can predict survival by analyzing relationships between standard hemodynamic measures, direct and NIRS measures of saturation, and outcome.
Journal ArticleDOI
Cerebral Oxygenation During Pediatric Cardiac Surgery Using Deep Hypothermia Circulatory Arrest
TL;DR: Brain oxygenation changed at distinct points during surgery in all ages, reflecting fundamental cerebral responses to hypothermic CPB, ischemia, and reperfusion, consistent with experimental work in animals.
Journal ArticleDOI
Sevoflurane anesthesia and brain perfusion
O. Rhondali,Agnès Pouyau,Aurélie Mahr,Simon Juhel,Mathilde De Queiroz,Khalid Rhzioual-Berrada,Sylvain Mathews,Dominique Chassard +7 more
TL;DR: To assess the impact of sevoflurane and anesthesia‐induced hypotension on brain perfusion in children younger than 6 months, a large number of patients were referred to the neonatal intensive care unit.
Journal ArticleDOI
An International, Multicenter, Observational Study of Cerebral Oxygenation during Infant and Neonatal Anesthesia
Vanessa A. Olbrecht,Justin Skowno,Vanessa Marchesini,Lili Ding,Yifei Jiang,Christopher G. Ward,Gaofeng Yu,Huacheng Liu,Bernadette Schurink,Laszlo Vutskits,Jurgen C. de Graaff,Francis X. McGowan,Britta S. von Ungern-Sternberg,C D Kurth,Andrew Davidson +14 more
TL;DR: Mild and moderate low cerebral oxygenation occurred frequently, whereas severe low cerebral saturation was uncommon, and low mean arterial pressure was common and not well associated withLow cerebral saturation.
Journal ArticleDOI
Impact of sevoflurane anesthesia on brain oxygenation in children younger than 2 years.
O. Rhondali,Simon Juhel,Sylvain Mathews,Quentin Cellier,François-Pierrick Desgranges,Aurélie Mahr,Mathilde De Queiroz,Agnès Pouyau,Khalid Rhzioual-Berrada,Dominique Chassard +9 more
TL;DR: To assess the impact of sevoflurane and anesthesia‐induced hypotension on brain oxygenation in children younger than 2 years, a large number of patients were referred to the neonatal intensive care unit.
References
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Journal Article
Abstract 2677: The influence of Systemic Hemodynamics and Oxygen Transport on Cerebral Oxygen Saturation in Neonates after the Norwood Procedure
Jia Li,Gencheng Zhang,Helen Holtby,Anne-Marie Guerguerian,Sally Cai,Tilman Humpl,Christopher A. Caldarone,Andrew N. Redington,Glen S. Van Arsdell +8 more
TL;DR: Cerebral oxygen saturation decreased significantly in neonates during the early postoperative period after the Norwood procedure and was significantly influenced by systemic hemodynamic and metabolic events.
Journal ArticleDOI
Perioperative cerebral and somatic oxygenation in neonates with hypoplastic left heart syndrome or transposition of the great arteries.
Anselm Uebing,Anke K. Furck,Jan Hinnerk Hansen,Elisabeth Nufer,Jens Scheewe,Peter Dütschke,Olaf Jung,Hans-Heiner Kramer +7 more
TL;DR: Depression of cerebral oxygen saturation is prevalent among neonates with congenital heart disease regardless of whether univentricular or biventricul circulation is present, suggesting that cerebral desaturation is mainly induced by CPB's effect on cerebral blood flow.
Journal ArticleDOI
Anesthesia practice standards at Harvard: a review.
John H. Eichhorn,Jeffrey B. Cooper,David J. Cullen,James S. Gessner,Robert S. Holzman,Ward R. Maier,James H. Philip +6 more
TL;DR: The Department of Anaesthesia of the Harvard Medical School has embraced formal promulgated standards of practice for certain components of anesthesia care rendered in the nine teaching hospital component departments that administered 112,000 anesthetics in 1987.
Journal ArticleDOI
Inclusion of oxygen consumption improves the accuracy of arterial and venous oxygen saturation interpretation after the Norwood procedure
Jia Li,Gencheng Zhang,Helen Holtby,Brian W. McCrindle,Sally Cai,Tilman Humpl,Christopher A. Caldarone,William G. Williams,Andrew N. Redington,Glen S. Van Arsdell +9 more
TL;DR: The close correlation of SVO2, Sa-VO2, and Omega to ERO2 indicates that each is a measure of the balance of DO2 and extraction, and may improve the optimization of postoperative management strategy in the individual neonate.
Journal ArticleDOI
Carbon dioxide--a complex gas in a complex circulation: its effects on systemic hemodynamics and oxygen transport, cerebral, and splanchnic circulation in neonates after the Norwood procedure.
Jia Li,Gencheng Zhang,Helen Holtby,Bruno Bissonnette,Golden Wang,Andrew N. Redington,Glen S. Van Arsdell +6 more
TL;DR: The increase in systemic blood flow is primarily a consequence of increased cerebral blood flow that compromises splanchnic circulation and the decrease in oxygen consumption improves oxygen transport, but the increase in catecholamines may be undesirable.
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