Journal ArticleDOI
Negative effects of melatonin on depression.
TLDR
Melatonin exacerbated symptoms of dysphoria in patients with Huntington's chorea and increased cerebrospinal fluid 5-hydroxyindoleacetic acid and calcium in three of four patients studied, and the authors discuss the implications of this finding.Abstract:
In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study. Melatonin exacerbated symptoms of dysphoria in these patients, as well as causing a loss of sleep and weight and a drop in oral temperature. Melatonin increased cerebrospinal fluid 5-hydroxyindoleacetic acid and calcium in three of four patients studied. The authors discuss the implications of this finding.read more
Citations
More filters
Journal ArticleDOI
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Rixt F. Riemersma-van der Lek,Dick F. Swaab,Jos W. R. Twisk,Elly M. Hol,Witte J.G. Hoogendijk,Eus J.W. Van Someren +5 more
TL;DR: Light has a modest benefit in improving some cognitive and noncognitive symptoms of dementia and is recommended only in combination with light to counteract the adverse effect of melatonin on mood.
Journal ArticleDOI
Melatonin: From Basic Research to Cancer Treatment Clinics
TL;DR: The evidence regarding the potential use of melatonin in cancer treatment is summarized and rationale for the design of larger translational research-based clinical trials is provided.
Journal ArticleDOI
Melatonin and sleep in humans.
Drew Dawson,Nicola Encel +1 more
TL;DR: The combined circadian and hypnotic effects of melatonin suggest a synergistic action in the treatment of sleep disorders related to the inappropriate timing of sleep and wakefulness.
Journal ArticleDOI
Melatonin as a radioprotective agent: a review.
TL;DR: Evidence is summarized that should be used to design larger translational research-based clinical trials using melatonin as a radioprotector and also in cancer radiotherapy and the potential use of melatonin for protecting individuals from radiation terrorism is considered.
Journal ArticleDOI
More than a marker: interaction between the circadian regulation of temperature and sleep, age-related changes, and treatment possibilities
TL;DR: This paper proposes that the circadian temperature rhythm provides an additional signaling pathway for the circadian modulation of sleep and wakefulness and reviews the relation among body temperature, arousal state, and the circadian timing system.
References
More filters
Journal ArticleDOI
The pineal gland: a neurochemical transducer.
TL;DR: In this article, Axelrod applied signal transduction theory to his research on the metabolic function of serotonin, even describing the pineal gland as a "neurochemical transducer."
Journal ArticleDOI
Methods for Reliable Longitudinal Observation of Behavior: Development of a Method for Systematic Observation of Emotional Behavior on Psychiatric Wards
TL;DR: This article developed a method for the observation and recording on a psychiatric ward of behavioral data which could be correlated with biochemical measurements and used to follow the "natural history" of a mental illness on a continuous day-to-day basis.
Journal ArticleDOI
On the effect of melatonin upon human brain. Its possible therapeutic implications.
TL;DR: Increase of EEG alpha activity, sleep, imagery, and a feeling of well-being and elation were found and a decrease in paroxistic grapho-elements of the epileptic patients was noticed.
Journal ArticleDOI
Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique.
TL;DR: Probenecid inhibits the removal of 5-HIAA and HVA (the major metabolites of serotonin and dopamine) from the cerebrospinal fluid, which was studied in patients with affective illness in order to assess central amine function.