Journal ArticleDOI
Melatonin: From Basic Research to Cancer Treatment Clinics
TLDR
The evidence regarding the potential use of melatonin in cancer treatment is summarized and rationale for the design of larger translational research-based clinical trials is provided.Abstract:
Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger, an indirect antioxidant, as well as an important immunomodulatory agent. In both in vitro and in vivo investigations, melatonin protected healthy cells from radiation-induced and chemotherapeutic drug-induced toxicity. Furthermore, several clinical studies have demonstrated the potential of melatonin, either alone or in combination with traditional therapy, to yield a favorable efficacy to toxicity ratio in the treatment of human cancers. This study reviews the literature from laboratory investigations that document the antioxidant and oncostatic actions of melatonin and summarizes the evidence regarding the potential use of melatonin in cancer treatment. This study also provides rationale for the design of larger translational research-based clinical trials.read more
Citations
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Journal ArticleDOI
Melatonin: Nature's most versatile biological signal?
Seithikurippu R. Pandi-Perumal,V. Srinivasan,Georges J.M. Maestroni,Daniel P. Cardinali,Burkhard Poeggeler,Rüdiger Hardeland +5 more
TL;DR: Melatonin is principally secreted at night and is centrally involved in sleep regulation, as well as in a number of other cyclical bodily activities, and its sleep-facilitating properties have been found to be useful for treating insomnia symptoms in elderly and depressive patients.
Journal ArticleDOI
Night-Shift Work and Risk of Colorectal Cancer in the Nurses’ Health Study
Eva S. Schernhammer,Francine Laden,Frank E. Speizer,Walter C. Willett,David J. Hunter,Ichiro Kawachi,Charles S. Fuchs,Graham A. Colditz +7 more
TL;DR: It is suggested that working a rotating night shift at least three nights per month for 15 or more years may increase the risk of colorectal cancer in women.
Journal ArticleDOI
Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients.
TL;DR: MBSR program enrollment was associated with enhanced quality of life and decreased stress symptoms in breast and prostate cancer patients, and resulted in possibly beneficial changes in hypothalamic-pituitary-adrenal (HPA) axis functioning.
Journal ArticleDOI
Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways.
Seithikurippu R. Pandi-Perumal,Ilya Trakht,Venkataramanujan Srinivasan,D. Warren Spence,Georges J.M. Maestroni,Nava Zisapel,Daniel P. Cardinali +6 more
TL;DR: The evidence concerning melatonin receptors and signal transduction pathways in various organs is reviewed and their relevance to circadian physiology and pathogenesis of certain human diseases, with a focus on the brain, the cardiovascular and immune systems, and cancer is considered.
Book ChapterDOI
Melatonin: a multitasking molecule.
TL;DR: Melatonin has revealed itself as an ubiquitously distributed and functionally diverse molecule that influences the molecular physiology of cells via receptor-independent means and may well find applications in both human and veterinary medicine.
References
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A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma
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Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
TL;DR: The pineal gland can be rapidly removed from rodents with minimal damage to adjacent neural structures using a specially designed trephine, and since the mid 1960s, research on the gland has become a very active area of investigation.
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The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide
TL;DR: The cage mechanism can explain the residual yield of nitrate that appears to be formed even in the presence of high concentrations of all of the scavengers studied to date, since scavengers capture only free HO. and .NO2 and not caged radicals.
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