Journal ArticleDOI
Neural mechanisms of aggression
Randy J. Nelson,Brian C. Trainor +1 more
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This Review summarizes the complex interactions between genes, biological signals, neural circuits and the environment that influence the development and expression of aggressive behaviour.Abstract:
Unchecked aggression and violence exact a significant toll on human societies. Aggression is an umbrella term for behaviours that are intended to inflict harm. These behaviours evolved as adaptations to deal with competition, but when expressed out of context, they can have destructive consequences. Uncontrolled aggression has several components, such as impaired recognition of social cues and enhanced impulsivity. Molecular approaches to the study of aggression have revealed biological signals that mediate the components of aggressive behaviour. These signals may provide targets for therapeutic intervention for individuals with extreme aggressive outbursts. This Review summarizes the complex interactions between genes, biological signals, neural circuits and the environment that influence the development and expression of aggressive behaviour.read more
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Anger Is an Approach-Related Affect: Evidence and Implications.
TL;DR: The authors review a range of evidence concerning the motivational underpinnings of anger as an affect, with particular reference to the relationship between anger and anxiety or fear, to support the view that anger relates to an appetitive or approach motivational system, whereas anxiety relates to aversive or avoidance motivational system.
Journal ArticleDOI
The role of medial prefrontal cortex in memory and decision making.
TL;DR: It is proposed that the function of the medial prefrontal cortex is to learn associations between context, locations, events, and corresponding adaptive responses, particularly emotional responses, and that mPFC likely relies on the hippocampus to support rapid learning and memory consolidation.
Journal ArticleDOI
The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis
TL;DR: A comprehensive comparative analysis of the two neural circuits of social behavior network and mesolimbic reward system concludes that they were already present in early vertebrates and proposes that these circuits form a larger social decision‐making (SDM) network that regulates adaptive behavior.
Journal ArticleDOI
Functional identification of an aggression locus in the mouse hypothalamus
Dayu Lin,Maureen P. Boyle,Piotr Dollár,Hyosang Lee,Ed S. Lein,Pietro Perona,David J. Anderson +6 more
TL;DR: It is shown that optogenetic, but not electrical, stimulation of neurons in the ventromedial hypothalamus, ventrolateral subdivision (VMHvl) causes male mice to attack both females and inanimate objects, as well as males.
Journal ArticleDOI
Discriminative and Affective Touch: Sensing and Feeling
TL;DR: It is proposed that a class of low-threshold mechanosensitive C fibers that innervate the hairy skin represent the neurobiological substrate for the affective and rewarding properties of touch.
References
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Book
The Expression of the Emotions in Man and Animals
TL;DR: The Expression of the Emotions in Man and Animals Introduction to the First Edition and Discussion Index, by Phillip Prodger and Paul Ekman.
Journal ArticleDOI
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
Journal ArticleDOI
Role of Genotype in the Cycle of Violence in Maltreated Children
Avshalom Caspi,Avshalom Caspi,Joseph L. McClay,Terrie E. Moffitt,Terrie E. Moffitt,Jonathan Mill,Judy Martin,Ian W. Craig,Alan Taylor,Richie Poulton +9 more
TL;DR: In this paper, a large sample of male children from birth to adulthood was studied to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not.
Journal ArticleDOI
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
Journal ArticleDOI
Serotonin Transporter Genetic Variation and the Response of the Human Amygdala
Ahmad R. Hariri,Venkata S. Mattay,Alessandro Tessitore,Bhaskar Kolachana,Francesco Fera,David Goldman,Michael F. Egan,Daniel R. Weinberger +7 more
TL;DR: Genetically driven variation in the response of brain regions underlying human emotional behavior is demonstrated and differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele.