Open AccessJournal Article
Neurochemical profile of tianeptine, a new antidepressant drug.
G Kato,A F Weitsch +1 more
Reads0
Chats0
TLDR
The major effect of tianeptine in rat platelets and synaptosomes is a small increase in 5-HT uptake after subchronic administration.Abstract:
Tianeptine is a new effective antidepressant drug. However, its neurochemical profile in animals differs from that of tricyclic or atypical antidepressants. In the present study, we compared the ex vivo effects of tianeptine on platelet serotonin uptake to those of clomipramine. Ex vivo, after subchronic (15 days, washout 24 h) treatment (10 mg/kg/day i.p.) in rats, tianeptine induced an increase (30%) in [14C]serotonin uptake at a [14C]serotonin concentration of 500 nM while clomipramine induced a decrease (40%) in [14C]serotonin uptake. Stimulation of uptake affected mainly Vmax but not Km. Tianeptine did not inhibit monoamine oxidase (MAO), MAOA or MAOB activity. In vitro, there was no binding of tianeptine to any of the various receptors examined: alpha- and beta-adrenergic, dopamine, serotonin, imipramine, GABA, glutamate, benzodiazepine, muscarinic, histamine, Ca2+ channels. After chronic administration (10 mg/kg/day for 15 days) tianeptine did not alter the concentration (Bmax) or the affinity (Kd) of alpha-2, beta-1, serotonin-1, serotonin-2, imipramine, benzodiazepine, or GABAB receptors. The major effect of tianeptine in rat platelets and synaptosomes is a small increase in 5-HT uptake after subchronic administration.read more
Citations
More filters
Journal ArticleDOI
The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?
Glenda MacQueen,Thomas Frodl +1 more
TL;DR: The clinical and biological correlates of small hippocampal volumes based on literature searches of PubMed and EMBASE are reviewed and the ways in which these data force a re-conceptualization of MDD are discussed.
Journal Article
Autoregulation of Serotonin Neurons: Role in Antidepressant Drug Action
Graciela Piñeyro,Pierre Blier +1 more
TL;DR: The existence of an endogenous vasoconstrictor in blood serum and the presence in the gut of a substance that increases intestinal motility had been known to scientists since the beginning of the century.
Journal ArticleDOI
The neurobiological properties of Tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation
Bruce S. McEwen,Sumantra Chattarji,David M. Diamond,Thérèse M. Jay,Thérèse M. Jay,Lawrence P. Reagan,Per Svenningsson,Eberhard Fuchs,Eberhard Fuchs +8 more
TL;DR: Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, which could provide a key pathway for its antidepressant action, and therefore offer new insights into how tianptine may be useful in the treatment of depressive disorders.
Journal ArticleDOI
Neurobiological and Clinical Effects of the Antidepressant Tianeptine
Siegfried Kasper,Bruce S. McEwen +1 more
TL;DR: The neurobiological properties of tianeptine may provide an explanation not only for its antidepressant activity, but also for its anxiolytic effects in depressed patients and its lack of adverse effects on cognitive function and memory.
Journal ArticleDOI
Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1β in the rat
TL;DR: This work, which is the first in vivo study assessing the effect of an antidepressant on centrally induced immune activation, shows a clear dissociation between peripheral and central cytokine effects, and suggests a peripheral site of action of tianeptine.