Neurological software tool for reliable atrophy measurement (NeuroSTREAM) of the lateral ventricles on clinical-quality T2-FLAIR MRI scans in multiple sclerosis.
Michael G. Dwyer,Diego Silva,Niels Bergsland,Dana Horakova,Deepa P. Ramasamy,Jaqueline Durfee,Manuela Vaneckova,Eva Havrdova,Robert Zivadinov +8 more
TLDR
Brain atrophy measurement on clinical quality T2-FLAIR scans is feasible, accurate, reliable, and relates to clinical outcomes.About:
This article is published in NeuroImage: Clinical.The article was published on 2017-01-01 and is currently open access. It has received 45 citations till now.read more
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Journal ArticleDOI
Slowly expanding/evolving lesions as a magnetic resonance imaging marker of chronic active multiple sclerosis lesions
Colm Elliott,Jerry S Wolinsky,Stephen L. Hauser,Ludwig Kappos,Frederik Barkhof,Corrado Bernasconi,Wei Wei,Shibeshih Belachew,Douglas L. Arnold +8 more
TL;DR: It is suggested that SELs reflect chronic tissue loss in the absence of ongoing acute inflammation, and may represent a conventional brain MRI correlate of chronic active MS lesions and a candidate biomarker for smoldering inflammation in MS.
Journal ArticleDOI
Assessing treatment outcomes in multiple sclerosis trials and in the clinical setting.
Carmen Tur,Marcello Moccia,Frederik Barkhof,Jeremy Chataway,Jeremy Chataway,Jaume Sastre-Garriga,Alan J. Thompson,Olga Ciccarelli,Olga Ciccarelli +8 more
TL;DR: Clinical, neuroimaging and composite outcome measures for MS, including patient-reported outcome measures, used in both trials and the clinical setting are discussed to help clinicians and researchers navigate through the multiple options encountered when choosing an outcome measure.
Journal ArticleDOI
Evidence of progressive tissue loss in the core of chronic MS lesions: A longitudinal DTI study.
Alexander Klistorner,Alexander Klistorner,Chenyu Wang,Con Yiannikas,John Parratt,Michael G. Dwyer,Joshua Barton,Stuart L. Graham,Yuyi You,Sidong Liu,Michael Barnett +10 more
TL;DR: A significant increase of isotropic water diffusion in the core of chronic stable MS lesions likely reflects gradual, self-sustained tissue destruction in demyelinated white matter that is more aggressive in males.
Journal ArticleDOI
Dietary and lifestyle factors in multiple sclerosis progression: results from a 5-year longitudinal MRI study
Dejan Jakimovski,Bianca Weinstock-Guttman,Sirin Gandhi,Yi Guan,Jesper Hagemeier,Deepa P. Ramasamy,Tom A. Fuchs,Richard W. Browne,Niels Bergsland,Michael G. Dwyer,Murali Ramanathan,Robert Zivadinov +11 more
TL;DR: Lifestyle risk factors contribute to accelerated central brain atrophy in MS patients, whereas unhealthier diet is associated with MS lesion accrual, despite the lower overall effect when compared to HCs.
Journal ArticleDOI
Aging and Brain Atrophy in Multiple Sclerosis
Emanuele Ghione,N. Bergsland,Michael G. Dwyer,Jesper Hagemeier,Dejan Jakimovski,Ivo Paunkoski,Deepa P. Ramasamy,Ellen Carl,David Hojnacki,Channa Kolb,Bianca Weinstock-Guttman,Robert Zivadinov +11 more
TL;DR: This work estimated the aging effect on lateral ventricular volume (LVV) and whole brain volume (WBV) changes in MS patients and confirmed that brain atrophy accelerates at the age of 60 in healthy individuals and at disease onset in multiple sclerosis patients.
References
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Fabian Pedregosa,Gaël Varoquaux,Alexandre Gramfort,Vincent Michel,Bertrand Thirion,Olivier Grisel,Mathieu Blondel,Peter Prettenhofer,Ron Weiss,Vincent Dubourg,Jake Vanderplas,Alexandre Passos,David Cournapeau,Matthieu Brucher,Matthieu Perrot,Edouard Duchesnay +15 more
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Scikit-learn: Machine Learning in Python
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