Journal ArticleDOI
New interview and observation measures of the broader autism phenotype: group differentiation.
Maretha de Jonge,Jeremy R. Parr,Jeremy R. Parr,Michael Rutter,Simon Wallace,Chantal Kemner,Anthony J. Bailey,Anthony J. Bailey,Herman van Engeland,Andrew Pickles +9 more
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TLDR
The measures do carry an important degree of validity; whether they can differentiate the BAP from other social disorders should be tested.Abstract:
To identify the broader autism phenotype (BAP), the Family History Interview subject and informant versions and an observational tool (Impression of Interviewee), were developed. This study investigated whether the instruments differentiated between parents of children with autism, and parents of children with Down syndrome (DS). The BAP scores of parents of 28 multiplex autism families were compared with parents from, 32 DS families. The BAP measures provided good group differentiation but when considered together, the subject interview did not improve group differentiation. The differentiation was better for fathers than mothers. The measures do carry an important degree of validity; whether they can differentiate the BAP from other social disorders should be tested.read more
Citations
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Journal ArticleDOI
Broader autism phenotype in parents of children with autism: a systematic review of percentage estimates.
TL;DR: Parental BAP may be an important tool for parsing heterogeneity in ASD etiology and for developing parent-mediated ASD interventions, but the variety in measurement instruments and variability in study samples limits the ability to synthesize estimates.
Journal ArticleDOI
Genetic advances in Autism
Anita Thapar,Michael Rutter +1 more
TL;DR: Some of the key findings that are shaping current understanding of autism and what these discoveries mean for clinicians are considered.
Journal ArticleDOI
De novo and rare inherited mutations implicate the transcriptional coregulator TCF20/SPBP in autism spectrum disorder
Christian Babbs,Deborah Lloyd,Alistair T. Pagnamenta,Stephen R.F. Twigg,Joanne Green,Simon J. McGowan,Ghazala Mirza,Rebecca Naples,Vikram P Sharma,Emanuela V. Volpi,Veronica J. Buckle,Steven A. Wall,Samantha J. L. Knight,Jeremy R. Parr,Andrew O.M. Wilkie +14 more
TL;DR: This study provides the first evidence that mutations in TCF20 are also associated with ASD, and independently identified a de novo frameshifting mutation of TCF 20 in a woman with ASD and moderate intellectual disability.
Journal ArticleDOI
Measuring the relationship between the parental Broader Autism Phenotype, parent–child interaction, and children’s progress following parent mediated intervention
TL;DR: In this article, a proof-of-principle analysis was carried out to investigate the impact of defined parent characteristics on early parent-mediated psychosocial interventions on children with ASD.
Journal ArticleDOI
Diagnosing autism spectrum disorder in community settings using the Development and Well-Being Assessment: Validation in a UK population-based twin sample
Fiona McEwen,Catherine Stewart,Catherine Stewart,Emma Colvert,Emma Woodhouse,Sarah Curran,Sarah Curran,Sarah Curran,Nicola Gillan,Victoria Hallett,Stephanie Lietz,Tracy Garnett,Angelica Ronald,Angelica Ronald,Declan G. Murphy,Declan G. Murphy,Francesca Happé,Patrick Bolton,Patrick Bolton +18 more
TL;DR: The DAWBA is a brief structured interview that showed good sensitivity and specificity in this general population sample and may help services implement the recommendations made by NICE and the American Academy of Pediatrics regarding diagnosis of young people on the autism spectrum.
References
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Journal ArticleDOI
Mullen Scales of Early Learning
TL;DR: The Mullen Scales of Early Learning (MSEL) as mentioned in this paper includes five scales that provide information on cognitive and motor ability, including Gross Motor (0-33 months only), Visual Reception, Fine Motor, Expressive Language and Receptive Language.
DatasetDOI
Autism Diagnostic Observation Schedule
Catherine Lord,Michael Rutter,Susan Goode,Jacquelyn Heemsbergen,Heather Jordan,Lynn Mawhood,Eric Schopler +6 more
Journal ArticleDOI
Epidemiology of pervasive developmental disorders.
TL;DR: There is evidence that the broadening of the concept, the expansion of diagnostic criteria, the development of services, and improved awareness of the condition have played a major role in explaining this increase, although it cannot be ruled out that other factors might have also contributed to that trend.
Book
Sex Differences in Antisocial Behaviour: Conduct Disorder, Delinquency, and Violence in the Dunedin Longitudinal Study
TL;DR: The recommendation to relax the criteria for diagnosing conduct disorder in girls and the effects of antisocial behaviour on young adult outcomes is evaluated.
Journal ArticleDOI
On the variances of asymptotically normal estimators from complex surveys
TL;DR: In this article, the problem of specifying and estimating the variance of estimated parameters based on complex sample designs from finite populations is considered and the results are particularly useful when the parameter estimators cannot be defined explicitly as a function of other statistics from the sample.