Journal ArticleDOI
Nitric oxide control of steroidogenesis: endocrine effects of NG-nitro-L-arginine and comparisons to alcohol.
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Results indicate that testicular and adrenal steroidogenesis are negatively regulated by endogenous NO and that NO does not regulate LH and PRL secretion or inhibit the testicular steroidogenic pathway in the same way as alcohol.About:
This article is published in Life Sciences.The article was published on 1992-01-01. It has received 134 citations till now. The article focuses on the topics: Luteinizing hormone & Corticosterone.read more
Citations
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Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
David A. Wink,James B. Mitchell +1 more
TL;DR: Various aspects of the chemical biology of NO relating to biological molecules such as guanylate cyclase, cytochrome P450, nitric oxide synthase, catalase, and DNA are discussed and the potential roles of NO in different biological events are explored.
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Role of nitric oxide in the biology, physiology and pathophysiology of reproduction
TL;DR: An overview of the role of NO in various reproductive organs under physiological and pathological conditions is provided.
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Nitric-Oxide - an Autocrine Regulator of Human Granulosa-Luteal Cell Steroidogenesis
TL;DR: It is concluded that NO synthase is present in human granulosa-luteal cells and that NO inhibits estradiol secretion independent of cGMP by directly inhibiting aromatase.
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The role of nitric oxide in oocyte meiotic maturation and ovulation: meiotic abnormalities of endothelial nitric oxide synthase knock-out mouse oocytes
TL;DR: The ovarian defects observed in the eNOS knock-out mice suggest that eN OS-derived NO is a modulator of oocyte meiotic maturation, and a role for NO in the ovulatory process is supported.
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Effect of sodium nitroprusside on sperm motility, viability, and lipid peroxidation
TL;DR: It is suggested that sodium nitroprusside is beneficial to the maintenance of post-thaw sperm motion and viability for up to 6 hours and that reduction of lipid peroxidative damage to sperm membranes may be the mechanism for these benefits.
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Nitric oxide: physiology, pathophysiology, and pharmacology
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Localization of nitric oxide synthase indicating a neural role for nitric oxide
TL;DR: It is demonstrated that NO synthase in the brain to be exclusively associated with discrete neuronal populations, and prominent neural localizations provided the first conclusive evidence for a strong association of NO with neurons.
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Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors.
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L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro.
TL;DR: The available data suggests that l‐NOARG, like l‐NMMA, inhibits endothelial nitric oxide (NO) biosynthesis and is identified as a potent, l‐arginine reversible inhibitor of endothelium‐dependent vasodilatation.