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nlme : Linear and nonlinear mixed effects models
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The article was published on 2006-01-01 and is currently open access. It has received 9437 citations till now.read more
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Convergent evolution of alternative developmental trajectories associated with diapause in African and South American killifish
TL;DR: It is reported that the ability to produce diapause eggs evolved independently at least six times within African and South American killifish and it is shown in species representative of these lineages that embryos entering diAPause display significant reduction in development of the cranial region and circulatory system relative to direct-developing embryos.
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The impact of work hour restrictions on surgical resident education.
TL;DR: The effect of reduced work hours on resident standardized test scores and operative volume at an institution was determined and an unexpected consequence of work-hour restrictions may be an improvement in surgical resident education.
Journal ArticleDOI
Climate-induced changes in bottom-up and top-down processes independently alter a marine ecosystem.
Malte Jochum,Florian D. Schneider,Florian D. Schneider,Tasman P. Crowe,Ulrich Brose,Eoin J. O'Gorman +5 more
TL;DR: The results of an in situ experiment examining the combined effects of top-down and bottom-up forces on the structure of a coastal marine community highlighted the possibility for climate-induced trophic cascades, driven by altered size structure of populations, rather than species extinction.
Journal ArticleDOI
Soil respiration fluxes in a temperate mixed forest: seasonality and temperature sensitivities differ among microbial and root-rhizosphere respiration.
Nadine K. Ruehr,Nina Buchmann +1 more
TL;DR: The partitioned soil respiration into microbial and root-rhizosphere respiration using small root exclusion treatments in a mixed mountain forest in Switzerland shows that root respiration and its apparent temperature sensitivity highly depend on plant phenology and thus on canopy assimilation and carbon allocation belowground.
Journal ArticleDOI
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking.
Samuele Ferrari,Aurelien Jacob,Stefano Beretta,Giulia Unali,Luisa Albano,Valentina Vavassori,Davide Cittaro,Dejan Lazarevic,Chiara Brombin,Federica Cugnata,Anna Kajaste-Rudnitski,Ivan Merelli,Pietro Genovese,Luigi Naldini +13 more
TL;DR: A barcoding strategy to clonal tracking of edited cells (BAR-Seq) is applied and it is shown that editing activates p53, which substantially shrinks the HSC clonal repertoire in hematochimeric mice, although engrafted edited clones preserve multilineage and self-renewing capacity.