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nlme : Linear and nonlinear mixed effects models
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The article was published on 2006-01-01 and is currently open access. It has received 9437 citations till now.read more
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Journal ArticleDOI
Detection of age-dependent changes in healthy adult lungs with diffusion-weighted 3He MRI.
Sean B. Fain,Talissa A. Altes,Talissa A. Altes,Shilpa R. Panth,Michael D. Evans,Barnaby Waters,John P. Mugler,Frank R. Korosec,Thomas M. Grist,Michael Silverman,Michael Salerno,John Owers-Bradley +11 more
TL;DR: Results suggest the observed age dependence of the ADC may be caused by changes in lung microstructure that increase alveolar volume during the aging process.
Journal ArticleDOI
Functional guild classification predicts the enzymatic role of fungi in litter and soil biogeochemistry
Jennifer M. Talbot,Francis Martin,Annegret Kohler,Bernard Henrissat,Bernard Henrissat,Kabir G. Peay +5 more
TL;DR: The hypothesis that key biological features of fungi - evolutionary history, functional guild, and abundance of functional genes – can predict the biogeochemical activity of fungal species during decay is tested and quantifying the specific functional guilds of fungi in soil is suggested.
Journal ArticleDOI
Rapid thermal adaptation in photosymbionts of reef-building corals.
Leela J. Chakravarti,Leela J. Chakravarti,Victor H. Beltran,Madeleine J. H. van Oppen,Madeleine J. H. van Oppen,Madeleine J. H. van Oppen +5 more
TL;DR: Using a reciprocal transplant design, it is shown that the upper temperature tolerance and temperature tolerance range of Symbiodinium C1 increased after ~80 asexual generations (2.5 years) of laboratory thermal selection, and the cause behind its limited transference to the coral holobiont in this genotypes is important next steps for developing methods that aim to increase coral bleaching tolerance.
Journal ArticleDOI
Predicting cyanobacterial dynamics in the face of global change: the importance of scale and environmental context
TL;DR: In this paper, the authors applied linear and nonlinear mixed-effect modeling techniques to seasonal time-series data from multiple lakes and found that the results showed that due to predictable interactions among nutrients and temperature, polymictic and dimictic lakes are expected to respond differently to future climate warming and eutrophication.
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Metagenome-Wide Association of Microbial Determinants of Host Phenotype in Drosophila melanogaster
TL;DR: The utility of MGWA is demonstrated for identifying bacterial determinants of host traits and mechanistic insight is provided into how gut microbiota modulate the nutritional status of a model host.