No association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican population
Carlos Alfonso Tovilla-Zárate,Beatriz Camarena Medellín,Ana Fresán,Lilia López-Narváez,Thelma Beatriz Gonzalez Castro,Isela Esther Juárez Rojop,Julian Ramírez-Bello,Alma Genis,Humberto Nicolini +8 more
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TLDR
It is suggested that the COMT gene may not contribute to the risk for schizophrenia among the Mexican population, and there is no evidence for an association between COMT and the clinical symptomatology of this illness.Abstract:
The gene coding for catecol-o-methyltransferase (COMT), participant in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. We determined the relation of the COMT Val108/158Met polymorphism with schizophrenia or its symptomatology (negative, disorganized and psychotic dimension). We conducted a case–control study comprising 186 patients with schizophrenia and 247 controls. The diagnosis of schizophrenia was established using the DSM-IV criteria for this illness. The clinical symptomatology was assessed through the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms. No significant differences were found in the distribution of alleles (χ2 = 0.01, df = 1, p = 0.90) or genotypes (χ2 = 1.66, df = 2, p = 0.43) between schizophrenic patients and the control group. Multivariate analysis showed that the COMT Val108/158Met polymorphism has no influence in the clinical symptomatology of schizophrenia. Our results showed no association between COMT Val108/158Met and schizophrenia or evidence for an association between COMT and the clinical symptomatology of this illness. This suggests that the COMT gene may not contribute to the risk for schizophrenia among the Mexican population.read more
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The 22q11.2 Deletion Syndrome as a Window into Complex Neuropsychiatric Disorders Over the Lifespan
TL;DR: An overview of neuropsychiatric findings to date highlights the value of this syndrome in mapping the developmental trajectory of dimensional phenotypes that traverse multiple diagnostic categories, and potential sources of genetic variability that may contribute to the disorder's heterogeneous presentation are reviewed.
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The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects
Thelma Beatriz González-Castro,Yazmín Hernández-Díaz,Isela Esther Juárez-Rojop,María Lilia López-Narváez,Carlos Alfonso Tovilla-Zárate,Ana Fresán +5 more
TL;DR: The analyses indicate that there is an association between COMT Val108/158Met and schizophrenia in the general population and in Caucasian populations, this risk could be increased.
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Alexis C. Edwards,Tim B. Bigdeli,Anna R. Docherty,Silviu Alin Bacanu,Donghyung Lee,Teresa R de Candia,Arden Moscati,Dawn L. Thiselton,Brion S. Maher,Brandon Wormley,Dermot Walsh,Francis A. O'Neill,Kenneth S. Kendler,Brien P. Riley,Ayman H. Fanous +14 more
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The role of brain-derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case-control study, comorbidities, and meta-analysis of 16,786 subjects.
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TL;DR: The aim of this study was to evaluate the association of Val66Met brain‐derived neurotrophic factor polymorphism with bipolar disorder in a meta‐analysis and a case–control study in a Mexican population.
References
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Journal ArticleDOI
Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.
Michael F. Egan,Terry E. Goldberg,Bhaskar Kolachana,Joseph H. Callicott,C.M. Mazzanti,Richard E. Straub,David Goldman,Daniel R. Weinberger +7 more
TL;DR: The data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia.
Journal ArticleDOI
A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies
TL;DR: The procedure reported here is the most economical, safe and rapid for preparation of DNA from whole blood and eliminates completely the use of proteinase K treatment.
Journal ArticleDOI
Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality
TL;DR: The epidemiology of schizophrenia is characterized by prominent variability and gradients that can help guide future research.
Journal ArticleDOI
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
Herbert M. Lachman,Demitri F. Papolos,Takuya Saito,Yue Min Yu,Carol L. Szumlanski,Richard M. Weinshilboum +5 more
TL;DR: The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur.