Journal ArticleDOI
Nonalcoholic fatty liver disease and vascular risk
TLDR
Although accumulating evidence points to nonalcoholic fatty liver disease emerging as a novel cardiovascular risk factor, more research is needed to find suitable noninvasive biomarkers of NAFLD severity to allow better risk-stratification based on cardiovascular outcomes.Abstract:
PURPOSE OF REVIEW: Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition, which is strongly associated with obesity and diabetes. The risk of cardiovascular disease is increased in NAFLD and represents the main cause of death in these patients. However, given the shared features between NAFLD, the metabolic syndrome and traditional cardiovascular risk factors, uncertainty exists as to whether NAFLD is an independent risk factor for increased cardiovascular disease. RECENT FINDINGS: Multiple epidemiological and case-control studies now demonstrate that NAFLD is associated with increased vascular risk, independently of conventional cardiometabolic risk factors. Evidence also suggests a graded association between NAFLD severity and increased vascular risk. However, given the heterogeneous disease spectrum of NAFLD, these findings have limitations with respect to accuracy of diagnosis and staging of NAFLD in most studies. SUMMARY: Although accumulating evidence points to NAFLD emerging as a novel cardiovascular risk factor, more research is needed to find suitable noninvasive biomarkers of NAFLD severity to allow better risk-stratification based on cardiovascular outcomes. Furthermore, with no established pharmacological treatment option for NAFLD currently available, any potential treatment must show efficacy not only in slowing liver disease progression, but also in ameliorating adverse cardiovascular outcomes.read more
Citations
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A systematic review: Burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; Should we care?
Ebenezer T Oni,Arthur S. Agatston,Arthur S. Agatston,Michael J. Blaha,Jonathan Fialkow,Ricardo C. Cury,Ricardo C. Cury,Andrei C. Sposito,Raimund Erbel,Ron Blankstein,Theodore Feldman,Mouaz H. Al-Mallah,Raul D. Santos,Matthew J. Budoff,Khurram Nasir +14 more
TL;DR: There is evidence to support the association of NAFLD with subclinical atherosclerosis independent of traditional risk factors and metabolic syndrome, however, there is need for future longitudinal studies to review this association to ascertain causality and include other ethnic populations.
Journal ArticleDOI
Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis
TL;DR: Similar proportions of patients with and without NASH survive for 1, 3, and 5 years after liver transplantation, however, patients with NASH are more likely to die from cardiovascular complications or sepsis.
Journal ArticleDOI
Clinical availability of nonalcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in korean men: 5‐year prospective cohort study
TL;DR: The development of type 2 DM is potentially more associated with more progressive NAFLD than a normal or milder state, and the potential availability ofNAFLD as an early predictor of type 1 diabetes mellitus is suggested.
Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: is there a link? [Review]
TL;DR: In this article, the potential adverse impact of non-alcoholic fatty liver disease (NAFLD) on kidney disease progression has been investigated, especially with respect to the implications for screening and surveillance strategies in patients with NAFLD.
Journal ArticleDOI
Nonalcoholic fatty liver disease - A multisystem disease?
Ivana Mikolašević,Sandra Milić,Tamara Turk Wensveen,Ivana Grgic,Ivan Jakopčić,Davor Štimac,Felix M. Wensveen,Lidija Orlić +7 more
TL;DR: In this paper, the effects of NAFLD extend beyond the liver and are negatively associated with a range of chronic diseases, most notably cardiovascular disease (CVD), diabetes mellitus type 2 (T2DM) and chronic kidney disease, as well as several other pathologies.
References
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