Proceedings ArticleDOI
Nonlinear two stage mechanotransduction model and neural response of Pacinian Corpuscle
Abhijit Biswas,M. Manivannan,Mandayam A. Srinivasan +2 more
- pp 1-4
TLDR
A biomechanical and neurophysiological model of skin and Pacinian Corpuscle (PC) to simulate its neural response over few 10s of Hz to 2000 Hz obtained from experiments to help in enhancing the technologies related to perception of vibration.Abstract:
This paper presents a biomechanical and neurophysiological model of skin and Pacinian Corpuscle (PC) to simulate its neural response over few 10s of Hz to 2000 Hz obtained from experiments. The PC neural responses are studied with sinusoidal stimuli to elucidate the relation between receptor potential and action potential and its variabilities. The overall model includes mechanical signal conditioning in both skin-layers and PC-lamellae, electro-mechanical transduction in the inner core of PC, followed by an improved Adaptive Relaxation Pulse Frequency Modulation (ARPFM). This model can be extended to simulate a group of PCs including many other variabilities in PC which will help in enhancing the technologies related to perception of vibration.read more
Citations
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Journal ArticleDOI
Multiscale Layered Biomechanical Model of the Pacinian Corpuscle
TL;DR: The model identifies a few generalizable features of the lamellar structure which makes it scalable for different sizes of PC with different number of lamellae and can be used for simulating a network of PCs considering their diversity for analyzing the high-frequency VT sensitivity of the human skin.
Journal ArticleDOI
Computational Parametric Analysis of the Mechanical Response of Structurally Varying Pacinian Corpuscles.
TL;DR: This study provides two simple expressions that can be used to predict the impact of structural or material changes with aging or disease on the frequency response of the PC.
Journal ArticleDOI
Micropipette aspiration of the Pacinian corpuscle
TL;DR: This study used micropipette aspiration to determine an apparent Young's modulus for PCs isolated from a cadaveric human hand, and estimated the PC to be on the same order of magnitude as skin or isolated cells, so it is recommended that a modulus in the kPa range be used in future studies.
References
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Journal ArticleDOI
Molecular basis of mechanotransduction in living cells
Owen P. Hamill,Boris Martinac +1 more
TL;DR: The simplest cell-like structure, the lipid bilayer vesicle, can respond to mechanical deformation by elastic membrane dilation/thinning and curvature changes and changes in local membrane curvature may shift the equilibrium between channel conformations.
Journal ArticleDOI
The structure and function of pacinian corpuscles: A review
Journal ArticleDOI
The Neural Coding of Stimulus Intensity: Linking the Population Response of Mechanoreceptive Afferents with Psychophysical Behavior
TL;DR: The neural code underlying the perception of stimulus intensity in the somatosensory system is investigated and it is concluded that stimulus intensity is best accounted for by the firing rate evoked in afferents located under or near the locus of stimulation, weighted by afferent type.
Journal Article
The neural coding of stimulus intensity: Linking the population response of mechanoreceptive afferents with psychophysical behavior (Journal of Neuroscience (October 24, 2007) (11687-11699))
Journal ArticleDOI
Mechanosensitive Ion Channels in Cultured Sensory Neurons of Neonatal Rats
TL;DR: Two distinct types of MS channels in sensory neurons that probably give rise to the observed MS whole-cell currents and transduce mechanical stimuli to neural signals involved in somatosensation, including pain are identified.