Journal ArticleDOI
Novel antimicrobial compounds identified using synthetic combinatorial library technology.
TLDR
A number of new antimicrobial and/or antifungal compounds have been successfully identified from pools of millions of other compounds.About:
This article is published in Trends in Biotechnology.The article was published on 1996-02-01. It has received 116 citations till now.read more
Citations
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Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.
TL;DR: The role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections.
Journal ArticleDOI
Diversity of antimicrobial peptides and their mechanisms of action.
Richard M. Epand,Hans J. Vogel +1 more
TL;DR: It is not likely that this diverse group of peptides has a single mechanism of action, but interaction of the peptides with membranes is an important requirement for most, if not all, antimicrobial peptides.
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Amphipathic, α‐helical antimicrobial peptides
TL;DR: This review considers alpha-helical, antimicrobial peptides from the point of view of six interrelated structural and physicochemical parameters that modulate their activity and specificity: sequence, size, structuring, charge, amphipathicity, and hydrophobicity.
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Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action.
TL;DR: In this review, the structures of a number of different Trp- and Arg-rich antimicrobial peptides are examined and some of the major mechanistic studies are presented.
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Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analyses.
Hazel M. Davey,Douglas B. Kell +1 more
TL;DR: Flow cytometry is a technique, which allows one to analyze cells rapidly and individually and permits the quantitative analysis of microbial heterogeneity, and offers many advantages over conventional measurements for both routine and more exploratory analyses of microbial properties.
References
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Journal ArticleDOI
Light-directed, spatially addressable parallel chemical synthesis.
TL;DR: High-density arrays formed by light-directed synthesis are potentially rich sources of chemical diversity for discovering new ligands that bind to biological receptors and for elucidating principles governing molecular interactions.
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Inactivation of antibiotics and the dissemination of resistance genes.
TL;DR: Although bacterial conjugation once was believed to be restricted in host range, it now appears that this mechanism of transfer permits genetic exchange between many different bacterial genera in nature.
Journal ArticleDOI
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
Richard A. Houghten,Clemencia Pinilla,Sylvie E. Blondelle,Jon R. Appel,Colette T. Dooley,Julio H. Cuervo +5 more
TL;DR: The precise identification of an antigenic determinant recognized by a monoclonal antibody as well as the straightforward development of new potent antimicrobial peptides are presented.
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An unnatural biopolymer
Charles Y. Cho,Edmund J. Moran,Sara Cherry,James C. Stephans,Stephen P. A. Fodor,Cynthia L. Adams,Arathi Sundaram,Jeffrey W. Jacobs,Peter G. Schultz +8 more
TL;DR: Oligocarbamates and other unnatural polymers may provide new frameworks for drug development and for testing theories of protein and peptide folding and structure.
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A priori delineation of a peptide which mimics a discontinuous antigenic determinant
TL;DR: A technique was developed for identifying peptides with high affinity for a given antibody by testing a monoclonal antibody directed against a discontinuous antigenic determinant on foot-and-mouth disease virus, and peptides mimicking the determinant were identified even though the tertiary structure of the proteins comprising the virus capsid is unknown.