Journal ArticleDOI
Nuclear factor-kappa B and cancer: its role in prevention and therapy
TLDR
Observations suggest that NF-kappaB is an ideal target for chemoprevention and chemosensitization and evidence supporting this hypothesis is reviewed.About:
This article is published in Biochemical Pharmacology.The article was published on 2002-09-01. It has received 493 citations till now. The article focuses on the topics: Transcription factor & Carcinogenesis.read more
Citations
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Cancer chemoprevention with dietary phytochemicals
TL;DR: Attention has recently been focused on intracellular-signalling cascades as common molecular targets for various chemopreventive phytochemicals.
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Molecular targets of dietary agents for prevention and therapy of cancer
TL;DR: Evidence is presented that numerous agents identified from fruits and vegetables can interfere with several cell-signaling pathways and the active principle identified in fruit and vegetables and the molecular targets modulated may be the basis for how these dietary agents not only prevent but also treat cancer and other diseases.
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Nuclear factor-κB: The enemy within
TL;DR: The NF-kappaB proteins themselves and proteins regulated by it have been linked to cellular transformation, proliferation, apoptosis suppression, invasion, angiogenesis, and metastasis as mentioned in this paper.
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Genetics and biology of pancreatic ductal adenocarcinoma
Haoqiang Ying,Prasenjit Dey,Wantong Yao,Alec C. Kimmelman,Giulio Draetta,Anirban Maitra,Ronald A. DePinho +6 more
TL;DR: The path to meaningful clinical progress has never been clearer to improve PDAC patient survival and a deeper understanding of cancer cell biology, particularly altered cancer cell metabolism and impaired DNA repair processes, is providing novel therapeutic strategies that show strong preclinical activity.
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Nuclear factor-κB: its role in health and disease
TL;DR: A review of the current knowledge of the physiological and pathophysiological functions of NF-kappaB and its possible role as a target of therapeutic intervention is presented in this article.
References
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THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
TL;DR: The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases.
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Activators and target genes of Rel/NF-kappaB transcription factors.
TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
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An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Amer A. Beg,David Baltimore +1 more
TL;DR: Reintroduction of RelA into RelA−/− fibroblasts resulted in enhanced survival, demonstrating that the presence ofrelA is required for protection from TNF-α.
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NF-κB: Ten Years After
TL;DR: The manuscript and the Figures and Table are based on a manuscript originally written by Gordon C. Dickinson in 2012 and then edited by David I. Dickinson and revised by David A. Dickinson.
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TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
TL;DR: The activation of the transcription factor nuclear factor-kappa B by tumor necrosis factor, ionizing radiation, or daunorubicin, was found to protect from cell killing, providing a mechanism of cellular resistance to killing by some apoptotic reagents.