Nuclear factor kappa-B and the heart.
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TLDR
Nuclear factor kappa-B may be a new therapeutic target for myocardial protection and a possible role of NFkappaB in the development of atherosclerosis and unstable coronary syndromes is discussed.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2001-08-01 and is currently open access. It has received 458 citations till now. The article focuses on the topics: Leukocyte adhesion molecule & Transcription factor.read more
Citations
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Role of Oxidative Modifications in Atherosclerosis
Roland Stocker,John F. Keaney +1 more
TL;DR: An "oxidative response to inflammation" model is proposed as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis.
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Nuclear factor-κB: its role in health and disease
TL;DR: A review of the current knowledge of the physiological and pathophysiological functions of NF-kappaB and its possible role as a target of therapeutic intervention is presented in this article.
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Gene Expression in Fibroblasts and Fibrosis: Involvement in Cardiac Hypertrophy
TL;DR: This review addresses the functional role played by cardiac fibroblasts and the molecular mechanisms that govern their activity during cardiac hypertrophy and remodeling, with a particular focus on the recent progress toward the understanding of the transcriptional regulatory mechanisms involved.
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Endothelial dysfunction: a comprehensive appraisal.
Ricardo J. Esper,Roberto A. Nordaby,Jorge O Vilariño,Antonio J. Paragano,José L. Cacharrón,José L. Cacharrón,Rogelio A. Machado +6 more
TL;DR: There is so much proof about endothelium dysfunction that it is reasonable to believe that there is diagnostic and prognostic value in its evaluation for the late outcome, and there is no doubt that endothelial dysfunction contributes to the initiation and progression of atherosclerotic disease and could be considered an independent vascular risk factor.
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Matrix Metalloproteinase-9: Many Shades of Function in Cardiovascular Disease
Andriy Yabluchanskiy,Yonggang Ma,Rugmani Padmanabhan Iyer,Michael E. Hall,Merry L. Lindsey,Merry L. Lindsey +5 more
TL;DR: The current understanding of M MP-9 physiology, including structure, regulation, activation, and downstream effects of increased MMP-9, is summarized.
References
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THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
TL;DR: The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases.
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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
TL;DR: Recently, significant advances have been made in elucidating the details of the pathways through which signals are transmitted to the NF-kappa B:I kappa B complex in the cytosol and their implications for the study of NF-Kappa B.
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Toll-like receptors in the induction of the innate immune response
Alan Aderem,Richard J. Ulevitch +1 more
TL;DR: A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.
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An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Amer A. Beg,David Baltimore +1 more
TL;DR: Reintroduction of RelA into RelA−/− fibroblasts resulted in enhanced survival, demonstrating that the presence ofrelA is required for protection from TNF-α.
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Suppression of TNF-α-Induced Apoptosis by NF-κB
TL;DR: In this paper, the sensitivity and kinetics of TNF-α-induced apoptosis were shown to be enhanced in a number of cell types expressing a dominant negative IkappaBalpha (Ikappa-BalphaM).