Nucleic acids spontaneously released by living frog auricles.
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This article is published in Biochemical Journal.The article was published on 1972-07-01 and is currently open access. It has received 71 citations till now. The article focuses on the topics: Nucleic acid.read more
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Liquid biopsy: monitoring cancer-genetics in the blood.
TL;DR: This Review will explore how tumour-associated mutations detectable in the blood can be used in the clinic after diagnosis, including the assessment of prognosis, early detection of disease recurrence, and as surrogates for traditional biopsies with the purpose of predicting response to treatments and the development of acquired resistance.
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About the possible origin and mechanism of circulating DNA apoptosis and active DNA release.
TL;DR: In this article, the authors show that extracellular DNA in different culture conditions favors apoptosis or spontaneous active DNA release in non-dividing cells, such as lymphocytes, frog auricles and cultured cell lines including HL-60, spontaneously release a nucleoprotein complex within a homeostatic system.
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Origins, structures, and functions of circulating DNA in oncology
TL;DR: A better understanding of the subsequent fate of cirDNA would help in deciphering its functional aspects such as their capacity for either genometastasis or their pro-inflammatory and immunological effects.
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Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients.
TL;DR: The results obtained in many different cancers have opened a new research area indicating that plasma DNA might eventually be a suitable target for the development of non-invasive diagnostic, prognostic and follow-up tests for cancer.
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Circulating (cell-free) nucleic acids – A promising, non-invasive tool for early detection of several human diseases
TL;DR: A review throws light on the current status of blood CNA as a diagnostic marker and its potential as a powerful tool in the future.