Journal ArticleDOI
Nucleus accumbens deep brain stimulation for a patient with self-injurious behavior and autism spectrum disorder: functional and structural changes of the brain: report of a case and review of literature
TLDR
The metabolism in the prefrontal and the frontal cortex as well as the occipital cortex was markedly decreased in association with the decreased cortical volumes in those areas 2 years after NAc DBS.Abstract:
The aim of this report was to investigate the clinical outcome of deep brain stimulation (DBS) for autism spectrum disorder (ASD) and the functional and structural changes in the brain after DBS. We present a 14-year-old boy with ASD and self-injurious behavior (SIB) refractory with medical and behavioral therapy. He was treated by bilateral nucleus accumbens (NAc) DBS. Remarkable clinical improvement was observed following NAc DBS. Brain fluorodeoxyglucose-positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) volumetric studies revealed that the metabolism in the prefrontal and the frontal cortex as well as the occipital cortex was markedly decreased in association with the decreased cortical volumes in those areas 2 years after NAc DBS. The therapeutic potential of NAc DBS is suggested for the clinical improvement of patients with ASD and SIB with structural and functional changes after DBS.read more
Citations
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Journal ArticleDOI
Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology
Ming Kai Pan,Yong Shi Li,Shi Bing Wong,Chun Lun Ni,Yi Mei Wang,Wen Chuan Liu,Liang Yin Lu,Jye Chang Lee,Etty Cortes,Jean Paul G. Vonsattel,Qian Sun,Qian Sun,Elan D. Louis,Phyllis L. Faust,Sheng-Han Kuo +14 more
TL;DR: A pathophysiologic contribution to tremor at molecular (GluRδ2), structural (CF-to-PC synapses), physiological (cerebellar oscillations), physiological and behavioral levels (kinetic tremor) that might have clinical applications for treating ET are identified.
Journal ArticleDOI
Amygdala and Hypothalamus: Historical Overview With Focus on Aggression.
Flavia Venetucci Gouveia,Clement Hamani,Clement Hamani,Erich Talamoni Fonoff,Helena Brentani,Helena Brentani,Eduardo Joaquim Lopes Alho,Rosa Magaly Campelo Borba de Morais,Aline Luz de Souza,Sergio P. Rigonatti,Raquel Chacon Ruiz Martinez +10 more
TL;DR: The rationale and neurobiological characteristics that may help to explain why functional neurosurgery has been proposed to control aggressive behavior are reviewed.
Journal ArticleDOI
The Dopamine Hypothesis of Autism Spectrum Disorder Revisited: Current Status and Future Prospects.
TL;DR: In this paper, the mesocorticolimbic and nigrostriatal pathways were identified as the core behavioral features of ASD, and a theoretical framework for a "dopamine hypothesis of ASD" which proposed that autistic behavior arises from a dysfunctional midbrain dopaminergic system.
Journal ArticleDOI
Structural, Functional, and Molecular Imaging of Autism Spectrum Disorder.
Xiaoyi Li,Kai Zhang,Xiao He,Jinyun Zhou,Chentao Jin,Lesang Shen,Yuanxue Gao,Mei Tian,Hong Zhang +8 more
TL;DR: A review of recent advances in neuroimaging studies that focused on ASD by using magnetic resonance imaging (MRI), PET, or single-positron emission tomography (SPECT) can be found in this article.
Journal ArticleDOI
New perspectives in the treatment of body dysmorphic disorder
TL;DR: A comprehensive summary of the current understanding of body dysmorphic disorder, including its clinical features, epidemiology, genetics, and current treatment modalities is provided.
References
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Deep brain stimulation for treatment-resistant depression.
Helen S. Mayberg,Helen S. Mayberg,Andres M. Lozano,Valerie Voon,Heather E. McNeely,David A. Seminowicz,Clement Hamani,Jason M. Schwalb,Sidney H. Kennedy +8 more
TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.
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Anticipation of increasing monetary reward selectively recruits nucleus accumbens.
TL;DR: Findings suggest that whereas other striatal areas may code for expected incentive magnitude, a region in the NAcc codes for expected positive incentive value, which is correlated with individual differences in self-reported happiness elicited by the reward cues.
Journal ArticleDOI
Prevalence of autism spectrum disorders in a total population sample
Young Shin Kim,Bennett L. Leventhal,Yun Joo Koh,Eric Fombonne,Eugene M. Laska,Eun Chung Lim,Keun-Ah Cheon,Soo Jeong Kim,Young Key Kim,Hyun Kyung Lee,Dong-Ho Song,Roy Richard Grinker +11 more
TL;DR: It is suggested that rigorous screening and comprehensive population coverage are necessary to produce more accurate ASD prevalence estimates and underscore the need for better detection, assessment, and services.
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Autism spectrum disorders: developmental disconnection syndromes.
Daniel H. Geschwind,Pat Levitt +1 more
TL;DR: A potential unifying model in which higher-order association areas of the brain that normally connect to the frontal lobe are partially disconnected during development can accommodate the specific neurobehavioral features observed in autism, their emergence during development, and the heterogeneity of autism etiology, behaviors and cognition.
Journal ArticleDOI
Three-Year Outcomes in Deep Brain Stimulation for Highly Resistant Obsessive–Compulsive Disorder
Benjamin D. Greenberg,Donald A. Malone,Gerhard Friehs,Ali R. Rezai,Cynthia S. Kubu,Paul Malloy,Stephen Salloway,Michael S. Okun,Wayne K. Goodman,Steven A. Rasmussen +9 more
TL;DR: Predictive long-term effects of DBS in highly treatment-resistant OCD improved, as did self-care, independent living, and work, school, and social functioning, and depression and anxiety also improved.