Obliterative bronchiolitis after lung and heart-lung transplantation: An analysis of risk factors and management
Ko Bando,Irvin L. Paradis,Shari L. Similo,Hiroaki Konishi,Kanshi Komatsu,Thomas G. Zullo,Samuel A. Yousem,John M. Close,Adriana Zeevi,Rene J. Duquesnoy,Jan D. Manzetti,Robert J. Keenan,John M. Armitage,Robert L. Hardesty,Bartley P. Griffith +14 more
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TLDR
Recipients with obliterative bronchiolitis detected in the preclinical stage were significantly more likely to be in remission than recipients who had clinical disease at the time of diagnosis and results indicate that acute rejection is the most significant risk factor for development of obliteration and that obliteration responds to treatment with augmented immunosuppression when it is detected early by surveillance transbronchial biopsy.About:
This article is published in The Journal of Thoracic and Cardiovascular Surgery.The article was published on 1995-07-01 and is currently open access. It has received 412 citations till now. The article focuses on the topics: Bronchiolitis & Transplantation.read more
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Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
TL;DR: The molecular and biochemical characterization of HOs is reviewed, with a discussion on the mechanisms of signal transduction and gene regulation that mediate the induction of HO-1 by environmental stress, to lay a foundation for potential future clinical applications of these systems.
Journal ArticleDOI
Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria.
Marc Estenne,Janet R. Maurer,Annette Boehler,Jim J. Egan,Adaani E. Frost,Marshall I. Hertz,George B. Mallory,Gregory I Snell,Samuel A. Yousem +8 more
TL;DR: This document update and summarize new information obtained from this research and incorporate, where appropriate, the results into the BOS criteria.
Journal ArticleDOI
Definitions of Cytomegalovirus Infection and Disease in Transplant Recipients
TL;DR: This study seeks to update the definitions of CMV on the basis of recent developments in diagnostic techniques, as well as to add to these definitions the concept of indirect effects caused by CMV.
Journal ArticleDOI
Immunobiology of Human Cytomegalovirus: from Bench to Bedside
Tania Crough,Rajiv Khanna +1 more
TL;DR: Over the last decade, knowledge of the immune response to HCMV infection in healthy virus carriers and diseased individuals has allowed us to translate these findings to develop better diagnostic tools and therapeutic strategies, and the application of these emerging technologies in the clinical setting is likely to provide opportunities for better management of patients with H CMV-associated diseases.
Journal ArticleDOI
An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome
Keith C. Meyer,Ganesh Raghu,Geert Verleden,Paul A. Corris,Paul Aurora,Kevin C. Wilson,Jan Brozek,Allan R. Glanville +7 more
TL;DR: The expert committee discussed the available research evidence and formulated specific recommendations about the use of systemic corticosteroids, cyclosporine, tacrolimus, azithromycin and about re-transplantation in patients with suspected and confirmed BOS.
References
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Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
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TL;DR: The text focuses on practical areas of statistics in terms of their relevance to biomedical applications, statistical hypothesis testing and estimation and an easy-to-use menu-driven program which performs 17 commonly used statistical tests featured in the text.
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A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts. International Society for Heart and Lung Transplantation.
Joel D. Cooper,M Billingham,Thomas M. Egan,Marshall I. Hertz,T Higenbottam,John P. Lynch,J Mauer,I Paradis,G.A. Patterson,C Smith +9 more
TL;DR: A clinically applicable, standardized method for assessing functional results after lung transplantation is required to evaluate factors that may affect long-term outcome, to permit comparison of results from different centers, and to evaluate results of clinical trials.
Journal ArticleDOI
Heart-lung transplantation: successful therapy for patients with pulmonary vascular disease.
Bruck A. Reitz,John Wallwork,Sharon A. Hunt,John L. Pennock,Margaret E. Billingham,Philip E. Oyer,Edward B. Stinson,Norman E. Shumway +7 more
TL;DR: In this paper, the authors reported their initial experience with three patients who received heart-lung transplants and used cyclosporin A as the primary immunosuppressive agent, although conventional drugs were also administered.