Open AccessJournal Article
On the immunocompetence of H-2 incompatible irradiation bone marrow chimeras.
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This article is published in Journal of Immunology.The article was published on 1980-05-01 and is currently open access. It has received 108 citations till now. The article focuses on the topics: Immunocompetence.read more
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The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.
TL;DR: Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency.
Journal ArticleDOI
Age, thymopoiesis, and CD4+ t-lymphocyte regeneration after intensive chemotherapy
Crystal L. Mackall,Thomas A. Fleisher,Margaret R. Brown,Mary P. Andrich,Clara C. Chen,Irwin M. Feuerstein,Marc E. Horowitz,Ian T. Magrath,Aziza T. Shad,Seth M. Steinberg,Leonard H. Wexler,Ronald E. Gress +11 more
TL;DR: Thymus-dependent regeneration of CD4+ T lymphocytes occurs primarily in children, whereas even young adults have deficiencies in this pathway, and the results suggest that rapid T-cell regeneration requires residual thymic function in patients receiving high-dose chemotherapy.
Journal ArticleDOI
Academic Research Underlying Industrial Innovations: Sources, Characteristics, and Financing
TL;DR: The authors conducted a systematic study of the characteristics of the universities and academic researchers that seem to have contributed most to industrial innovation and how such academic research has been funded, based on data obtained from 66 firms in seven major manufacturing industries and from over 200 academic researchers.
Journal ArticleDOI
Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts
TL;DR: Reconstituting the irradiated host with T-cell depleted bone marrow containing both host (syngeneic) and donor (allogeneic or xenogeneic) components leads to long-term survival of the reconstituted animals and specific prolongation of subsequent skin grafts of donor type.
Journal ArticleDOI
Transplantation for severe combined immunodeficiency with HLA-A,B,D,DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells.
Yair Reisner,Kapoor N,D Kirkpatrick,Pollack,Susanna Cunningham-Rundles,Bo Dupont,MZ Hodes,Robert A. Good,R.J. O'Reilly +8 more
TL;DR: This article showed that depletion of T lymphocytes by this technique can abrogate the potential of histoincompatible marrow grafts to induce lethal GVHD without limiting immunologic reconstitution.
Related Papers (5)
Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts
Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen.
Sharabi Y,David H. Sachs +1 more