One-Step Cartilage Repair with Bone Marrow Aspirate Concentrated Cells and Collagen Matrix in Full-Thickness Knee Cartilage Lesions Results at 2-Year Follow-up
Alberto Gobbi,Georgios Karnatzikos,Celeste Scotti,Vivek Mahajan,Laura Mazzucco,Brunella Grigolo +5 more
TLDR
1-step surgery with BMAC and collagen I/III matrix could be a viable technique in the treatment of grade IV knee chondral lesions and showed significant improvement in all scores at final follow-up.Abstract:
Objective:The purpose of our study was to determine the effectiveness of cartilage repair utilizing 1-step surgery with bone marrow aspirate concentrate (BMAC) and a collagen I/III matrix (Chondro-...read more
Citations
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MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment.
TL;DR: The current understanding of MSC exosomes is reviewed, the possible mechanisms of action in cartilage repair are discussed, and new perspectives for development of an off-the-shelf and cell-free MSC therapy for treatment of cartilage injuries and osteoarthritis are provided.
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Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics
TL;DR: Despite the growing interest in this biological approach for cartilage regeneration, knowledge on this topic is still preliminary, as shown by the prevalence of preclinical studies and the presence of low-quality clinical studies.
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Concentrated Bone Marrow Aspirate for the Treatment of Chondral Injuries and Osteoarthritis of the Knee: A Systematic Review of Outcomes
Jorge Chahla,Chase S. Dean,Gilbert Moatshe,Cecilia Pascual-Garrido,Raphael Serra Cruz,Robert F. LaPrade +5 more
TL;DR: A systematic review of the literature on the outcomes of bone marrow aspirate concentrate for the treatment of chondral defects and osteoarthritis of the knee found varying degrees of beneficial results with the use of BMAC with and without an additional procedure.
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One-Step Surgery With Multipotent Stem Cells for the Treatment of Large Full-Thickness Chondral Defects of the Knee
TL;DR: The treatment of large chondral defects with MSCs is an effective procedure and can be performed routinely in clinical practice, and is achieved with 1-step surgery, avoiding a previous surgical procedure to harvest cartilage and subsequent chondrocyte cultivation.
Journal ArticleDOI
Mesenchymal stem cells in the treatment of traumatic articular cartilage defects: a comprehensive review.
TL;DR: Further investigation is required to establish a consensus on techniques for treatment of chondral and osteochondral defects with respect to cell source, isolation and expansion, implantation density, in vitro precultivation, and scaffold composition to allow for further optimization of MSC proliferation, chondrogenic differentiation, bio engineered cartilage integration, and clinical outcome.
References
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Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
TL;DR: Cultured autologous chondrocytes can be used to repair deep cartilage defects in the femorotibial articular surface of the knee joint.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal stem cells as trophic mediators.
Arnold I. Caplan,James E. Dennis +1 more
TL;DR: Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of M SC‐mediated trophic effects in tissue repair.
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In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
TL;DR: A culture system that facilitates the chondrogenic differentiation of rabbit bone marrow-derived mesenchymal progenitor cells has been developed in this article, where cells obtained in bone marrow aspirates were first isolated by monolayer culture and then transferred into tubes and allowed to form three-dimensional aggregates in a chemically defined medium.
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Chondrogenic Differentiation of Cultured Human Mesenchymal Stem Cells from Marrow
Alastair Morgan Mackay,Stephen C. Beck,J. Mary Murphy,Frank Barry,Clinton O. Chichester,Mark F. Pittenger +5 more
TL;DR: Increased understanding of the induction of chondrogenic differentiation should lead to further progress in defining the mechanisms responsible for the generation of cartilaginous tissues, their maintenance, and their regeneration.