Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain
Reads0
Chats0
TLDR
The similarities and differences in opioid receptor-mediated regulation of neurotransmission across different brain regions are explored and how future studies can consider potential cell-type, regional, and neural pathway-specific effects of opioid receptors in order to better understand how opioid receptors modulate brain function is understood.Abstract:
Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons. However, opioid receptor-mediated regulation of neuronal function and synaptic transmission is not uniform in expression pattern and mechanism across the brain. The localization of receptors within specific cell types and neurocircuits determine the effects that endogenous and exogenous opioids have on brain function. In this review we will explore the similarities and differences in opioid receptor-mediated regulation of neurotransmission across different brain regions. We discuss how future studies can consider potential cell-type, regional, and neural pathway-specific effects of opioid receptors in order to better understand how opioid receptors modulate brain function.read more
Citations
More filters
Journal ArticleDOI
Molecular pathways of major depressive disorder converge on the synapse
TL;DR: Considering the pattern of synaptic activity as the closest physical representation of mood, emotion, and conscience the authors can conceptualize, each pathway or molecular system will be scrutinized for links to neurotransmission.
Journal ArticleDOI
Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development
TL;DR: In this article , the authors focus on prenatal opioid exposure (POE) given the significant concern for the mental health outcomes of children with parents affected by opioid use disorder (OUD) in the view of the current opioid crisis.
Journal ArticleDOI
Opioids induce bidirectional synaptic plasticity in a brainstem pain centre in the rat.
Valeria Mussetto,H. L. Teuchmann,Bernhard Heinke,Lidia Trofimova,Jürgen Sandkühler,Ruth Drdla-Schutting,Roni Hogri +6 more
TL;DR: In this paper , the authors demonstrate a concentration-dependent, bimodal effect of opioids on excitatory synaptic transmission in the lateral parabrachial nucleus (LPBN) in the brainstem.
Journal ArticleDOI
Shared Mechanisms of GABAergic and Opioidergic Transmission Regulate Corticolimbic Reward Systems and Cognitive Aspects of Motivational Behaviors
TL;DR: The functional interplay between the corticolimbic GABAergic and opioidergic systems plays a crucial role in regulating the reward system and cognitive aspects of motivational behaviors leading to the development of addictive behaviors and disorders as mentioned in this paper .
Journal ArticleDOI
Validation of a pharmacological imaging challenge using 11C-buprenorphine and 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography to study the effects of buprenorphine to the rat brain
Amélie Soyer,Sarah Leterrier,Louise Breuil,Maud Goislard,Claire Leroy,Wadad Saba,Karine Thibault,Gregory Dal Bo,Michel Bottlaender,Fabien Caillé,Sébastien Goutal,Nicolas Tournier +11 more
TL;DR: In this paper , a single dose of buprenorphine (0.1 mg/kg, s.c) was investigated through blocking experiments using 11C-buprinorphine PET imaging.
References
More filters
Journal ArticleDOI
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
TL;DR: Progress in identifying candidate mechanisms of addiction is reviewed, including molecular and cellular mechanisms that underlie long-term associative memories in several forebrain circuits (involving the ventral and dorsal striatum and prefrontal cortex) that receive input from midbrain dopamine neurons.
Journal ArticleDOI
The structure and function of G-protein-coupled receptors
TL;DR: G-protein-coupled receptors mediate most of the authors' physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases.
Journal ArticleDOI
Opioids excite dopamine neurons by hyperpolarization of local interneurons.
Steven W. Johnson,R. A. North +1 more
TL;DR: It is concluded that hyperpolarization of the interneurons by opioids reduces the spontaneous GABA-mediated synaptic input to the dopamine cells in vivo, which would be expected to contribute to the positive reinforcement seen with mu-receptor agonists such as morphine and heroin.
Journal ArticleDOI
Synaptic plasticity: multiple forms, functions, and mechanisms.
Ami Citri,Robert C. Malenka +1 more
TL;DR: Current understanding of the mechanisms of the major forms of synaptic plasticity at excitatory synapses in the mammalian brain are reviewed.
Journal ArticleDOI
The Amygdaloid Complex: Anatomy and Physiology
TL;DR: The anatomical and physiological substrates proposed to underlie amygdala function are examined, suggesting that long-term synaptic plasticity of inputs to the amygdala underlies the acquisition and perhaps storage of the fear memory.
Related Papers (5)
Long-term effects on brain opioid and opioid receptor like-1 receptors after short periods of maternal separation in rats.
Karolina Ploj,Ingrid Nylander +1 more