Journal ArticleDOI
Optical coherence tomography and microscopy in gastrointestinal tissues
Joseph A. Izatt,Manish D. Kulkarni,Hsing-Wen Wang,Kenji Kobayashi,Michael V. Sivak +4 more
- Vol. 2, Iss: 4, pp 56-57
TLDR
Optical coherence tomography (OCT) and optical coherence microscopy (OCM) are novel techniques for noninvasive biomedical imaging based on low-coherence interferometry.Abstract:
Optical coherence tomography (OCT) and optical coherence microscopy (OCM) are novel techniques for noninvasive biomedical imaging based on low-coherence interferometry. OCT achieves high-spatial resolution ( 100 dB) in a fiber-optically integrated system which is suitable for application in minimally invasive diagnostics, including endoscopy. The technique of OCM combines the depth-ranging capability of OCT with the micron-scale resolution imaging capability of confocal microscopy to extend the available imaging depth of confocal microscopy up to several hundred micrometers deep in highly scattering tissues. The theoretical and technical bases for OCT and OCM imaging are described. Example OCT images are provided in gastrointestinal (GI) tissues to illustrate contrast between histological layers of the GI mucosa and differentiation of the mucosa from submucosa. Example OCM images revealing cellular-level microstructure up to several hundred micrometers deep in GI tissue are presented for the first time. The potential applications of OCT and OCM imaging in clinical diagnostic medicine are discussed.read more
Citations
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Journal ArticleDOI
Optical coherence tomography - principles and applications
TL;DR: OCT as discussed by the authors synthesises cross-sectional images from a series of laterally adjacent depth-scans, which can be used to assess tissue and cell function and morphology in situ.
Journal Article
Optical Coherence Tomography of the Human Retina
Michael R. Hee,Joseph A. Izatt,Eric A. Swanson,David Huang,Joel S. Schuman,Charles P. Lin,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: In this article, optical coherence tomography is used for high-resolution, noninvasive imaging of the human retina, including the macula and optic nerve head in normal human subjects.
Journal ArticleDOI
Optical coherence tomography (OCT): a review
TL;DR: The state of the art of optical coherence tomography (OCT), an interferometric imaging technique that provides cross-sectional views of the subsurface microstructure of biological tissue is reviewed.
Journal ArticleDOI
Optical coherence tomography for ultrahigh resolution in vivo imaging
TL;DR: Optical coherence tomography functions as a type of 'optical biopsy' to provide cross-sectional images of tissue structure on the micron scale and is a promising imaging technology because it can provide images of tissues in situ and in real time, without the need for excision and processing of specimens.
Journal ArticleDOI
Optical Coherence Tomography: An Emerging Technology for Biomedical Imaging and Optical Biopsy
James G. Fujimoto,Costas Pitris,Costas Pitris,Stephen A. Boppart,Stephen A. Boppart,Mark E. Brezinski +5 more
TL;DR: OCT can be used where standard excisional biopsy is hazardous or impossible, to reduce sampling errors associated with excisionality, and to guide interventional procedures, and its potential biomedical and clinical applications are described.
References
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Book
Probability, random variables and stochastic processes
TL;DR: This chapter discusses the concept of a Random Variable, the meaning of Probability, and the axioms of probability in terms of Markov Chains and Queueing Theory.
Book
Probability, random variables, and stochastic processes
TL;DR: In this paper, the meaning of probability and random variables are discussed, as well as the axioms of probability, and the concept of a random variable and repeated trials are discussed.
Journal ArticleDOI
Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Book ChapterDOI
Optical Coherence Tomography
Eric A. Swanson,J. Izatt,M. Bee,David Huang,Charles P. Lin,Carmen A. Puliafito,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease as mentioned in this paper, where OCT is an interferometric technique that detects reflected and backscattered light from tissue.
Book
Random variables and stochastic processes
TL;DR: An electromagnetic pulse counter having successively operable, contact-operating armatures that are movable to a rest position, an intermediate position and an active position between the main pole and the secondary pole of a magnetic circuit.