Optical Coherence Tomography: An Emerging Technology for Biomedical Imaging and Optical Biopsy
James G. Fujimoto,Costas Pitris,Costas Pitris,Stephen A. Boppart,Stephen A. Boppart,Mark E. Brezinski +5 more
TLDR
OCT can be used where standard excisional biopsy is hazardous or impossible, to reduce sampling errors associated with excisionality, and to guide interventional procedures, and its potential biomedical and clinical applications are described.About:
This article is published in Neoplasia.The article was published on 2000-01-01 and is currently open access. It has received 981 citations till now. The article focuses on the topics: Optical Biopsy & Optical coherence tomography.read more
Citations
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Journal ArticleDOI
Optical coherence tomography - principles and applications
TL;DR: OCT as discussed by the authors synthesises cross-sectional images from a series of laterally adjacent depth-scans, which can be used to assess tissue and cell function and morphology in situ.
Journal Article
Optical Coherence Tomography of the Human Retina
Michael R. Hee,Joseph A. Izatt,Eric A. Swanson,David Huang,Joel S. Schuman,Charles P. Lin,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: In this article, optical coherence tomography is used for high-resolution, noninvasive imaging of the human retina, including the macula and optic nerve head in normal human subjects.
Journal Article
In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography
Guillermo J. Tearney,Mark E. Brezinski,Brett E. Bouma,Stephen A. Boppart,Costas Pitris,James F. Southern,James G. Fujimoto +6 more
TL;DR: In this article, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter, which was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.
Journal ArticleDOI
Optical coherence tomography for ultrahigh resolution in vivo imaging
TL;DR: Optical coherence tomography functions as a type of 'optical biopsy' to provide cross-sectional images of tissue structure on the micron scale and is a promising imaging technology because it can provide images of tissues in situ and in real time, without the need for excision and processing of specimens.
Journal ArticleDOI
Ultrahigh-resolution optical coherence tomography using continuum generation in an air-silica microstructure optical fiber.
Ingmar Hartl,Xingde Li,C. Chudoba,Ravi K. Ghanta,Tony H. Ko,James G. Fujimoto,Jinendra Kumar Ranka,Robert S. Windeler +7 more
TL;DR: Ultrahigh-resolution optical coherence tomography (OCT) using continuum generation in an air-silica microstructure fiber as a low-coherence light source and imaging in biological tissue in vivo was demonstrated.
References
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Journal ArticleDOI
Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Book ChapterDOI
Optical Coherence Tomography
Eric A. Swanson,J. Izatt,M. Bee,David Huang,Charles P. Lin,Carmen A. Puliafito,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease as mentioned in this paper, where OCT is an interferometric technique that detects reflected and backscattered light from tissue.
Journal ArticleDOI
The pathogenesis of coronary artery disease and the acute coronary syndromes (1).
TL;DR: The two hypotheses to explain the pathogenesis of atherosclerosis, the "incrustation" hypothesis and the "lipid" hypothesis, are now known.
Journal ArticleDOI
Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.
M J Davies,A C Thomas +1 more
TL;DR: This controversy was concerned with whether coronary artery thrombi were or were not directly responsible for all three clinical pictures of acute ischaemia.