Journal ArticleDOI
Optical tomographic imaging of small animals.
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The past three years have seen an array of novel technological developments that have led to the first optical tomographic studies of small animals in the areas of cerebral ischemia and cancer.About:
This article is published in Current Opinion in Biotechnology.The article was published on 2005-02-01. It has received 217 citations till now. The article focuses on the topics: Diffuse optical imaging & Preclinical imaging.read more
Citations
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Journal ArticleDOI
X-ray-Computed Tomography Contrast Agents
Hrvoje Lusic,Mark W. Grinstaff +1 more
TL;DR: The strong relationship between absorption and atomic number is of significant importance in clinical applications and the Z4 factor allows for contrast levels of several orders of magnitude between different tissues and types of contrast agents.
Journal ArticleDOI
Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci.
Mandana Veiseh,Patrik Gabikian,S-Bahram Bahrami,Omid Veiseh,Miqin Zhang,Robert C. Hackman,Ali C. Ravanpay,Mark R. Stroud,Yumiko Kusuma,Stacey Hansen,Deborah Kwok,Nina M. Muñoz,Raymond W. Sze,William M. Grady,Norman M. Greenberg,Richard G. Ellenbogen,James M. Olson +16 more
TL;DR: Mouse studies revealed that CTX:Cy5.5 has the potential to fundamentally improve intraoperative detection and resection of malignancies and has favorable biodistribution and toxicity profiles.
Journal ArticleDOI
Whole-body three-dimensional optoacoustic tomography system for small animals
Hans-Peter Brecht,Richard Su,Matthew P. Fronheiser,Sergey A. Ermilov,André Conjusteau,Alexander A. Oraevsky +5 more
TL;DR: A system for three-dimensional whole-body optoacoustic tomography of small animals for applications in preclinical research and capable of generating images of individual organs and blood vessels through the entire body of a mouse with spatial resolution of approximately 0.5 mm.
Journal ArticleDOI
Light transport in biological tissue based on the simplified spherical harmonics equations
TL;DR: It is concluded that the simplified spherical harmonics methods can accurately model light propagation in small tissue geometries at visible and near-infrared wavelengths, yielding transport-like solutions with only a fraction of the computational cost of the transport calculation.
Journal ArticleDOI
Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain.
TL;DR: The image reconstruction was optimized using a noise model for diffuse correlation tomography which enabled better data selection and regularization in 3D tomography of cerebral blood flow in small animal models.
References
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Journal ArticleDOI
Optical tomography in medical imaging
TL;DR: A review of methods for the forward and inverse problems in optical tomography can be found in this paper, where the authors focus on the highly scattering case found in applications in medical imaging, and to the problem of absorption and scattering reconstruction.
Journal ArticleDOI
Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties.
TL;DR: A simple model is developed, based on the diffusion approximation to radiative transfer theory, which yields analytic expressions for the pulse shape in terms of the interaction coefficients of a homogeneous slab.
BookDOI
Optical-Thermal Response of Laser-Irradiated Tissue
TL;DR: Welch et al. as discussed by the authors proposed a Monte Carlo Modeling of Light Transport in Tissue S.C. van Gemert, A.J. van Leeuwen, et al., and C.C., Svaasand.
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Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging.
TL;DR: FMT, a technique that can three-dimensionally image gene expression by resolving fluorescence activation in deep tissues by focusing on optical imaging technologies used for non-invasive imaging of the distribution of such probes, is discussed.
Journal ArticleDOI
Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation.
TL;DR: The cytochrome aa3 spectrum in vivo from the brains of rats after replacing the blood with a fluorocarbon substitute is obtained and an algorithm for calculating the changes in oxygenated and deoxygenated haemoglobin and oxygenated cy tochrome a a3 in tissue from changes in near IR absorption is constructed.