Oral nano-curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease-19 patients: An open label nonrandomized clinical trial.
Niloofar Saber-Moghaddam,Soofia Salari,Sepideh Hejazi,Mahnaz Amini,Zhila Taherzadeh,Saeed Eslami,Seyed Mahdi Rezayat,Mahmoud Reza Jaafari,Sepideh Elyasi +8 more
TLDR
Wang et al. as mentioned in this paper proposed nano-curcumin as a potential treatment option for coronavirus disease-19 (COVID-19) by inhibiting the virus entrance, encapsulation and replication, and modulating various cellular signaling pathways.Abstract:
Curcumin is proposed as a potential treatment option for coronavirus disease-19 (COVID-19) by inhibiting the virus entrance, encapsulation and replication, and modulating various cellular signaling pathways. In this open-label nonrandomized clinical trial, efficacy of nano-curcumin oral formulation has been evaluated in hospitalized patients with mild-moderate COVID-19. Forty-one patients who fulfilled the inclusion criteria were allocated to nano-curcumin (n = 21) group (Sinacurcumin soft gel, contains 40 mg curcuminoids as nanomicelles, two capsules twice a day) or control (n = 20) group, for 2 weeks. Patients' symptoms and laboratory data were assessed at baseline and during follow-up period. Most of symptoms including fever and chills, tachypnea, myalgia, and cough resolved significantly faster in curcumin group. Moreover, SaO2 was significantly higher in treatment group after 2, 4, 7, and 14 days of follow-up and lymphocyte count after 7 and 14 days. Duration of supplemental O2 use and hospitalization was also meaningfully shorter in treatment group. It is also noteworthy to mention that no patient in treatment group experienced deterioration of infection during follow-up period, but it occurred in 40% of control group. Oral curcumin nano-formulation can significantly improve recovery time in hospitalized COVID-19 patients. Further randomized placebo controlled trials with larger sample size are recommended.read more
Citations
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Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures.
Ying Peng,Mingyue Ao,Baohua Dong,Yunxiu Jiang,Lingying Yu,Zhimin Chen,Changjiang Hu,Runchun Xu +7 more
TL;DR: Wang et al. as mentioned in this paper reviewed the anti-inflammatory effect of curcumin, the inflammatory pathological mechanism of related diseases, the regulatory effect of Curcumin on these, and the latest research results on the improvement of curcan pharmacokinetics.
Journal ArticleDOI
Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials
Amir Vahedian-Azimi,Mitra Abbasifard,Farshid Rahimibashar,Paul C. Guest,Muhammed Majeed,Asadollah Mohammadi,Maciej Banach,Tannaz Jamialahmadi,Amirhossein Sahebkar +8 more
TL;DR: It is suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance in COVID-19 patients.
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Curcumin: Biological Activities and Modern Pharmaceutical Forms
Maja Urosevic,Ljubiša Nikolić,Ivana M. Savic Gajic,Vesna Nikolić,Anka Dinić,Vojkan Miljković +5 more
TL;DR: An overview of recent research in biological and pharmaceutical aspects of curcumin is provided to provide an overview of methods of sample preparation for its isolation, analytical methods for identification and quantification ofCurcumin in different matrices, and different techniques for developing formulations.
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Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential.
TL;DR: In this article, the authors highlighted the recent evidence of curcuminoids applied in sevral aspects of medical problem particular in COVID-19 pandemics, and provided deeper insight and understandings of Curcumin's medicinal value in the discovery and development of new drugs.
Journal ArticleDOI
Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets
Hitesh Chopra,Protity Shuvra Dey,Debashrita Das,Tanima Bhattacharya,Muddaser Shah,Sidra Mubin,Samka Peregrine Maishu,Rokeya Akter,Md. Habibur Rahman,Chenmala Karthika,Waheed Murad,Naeem Qusty,Safaa Y. Qusti,Eida M. Alshammari,Gaber El-Saber Batiha,Farag M. A. Altalbawy,Mona I. M. Albooq,Badrieah M. Alamri +17 more
TL;DR: In this paper, the authors discussed nano-formulation techniques, which lend support to upgrade the characters to the curcumin such as enhancing bioavailability, increasing solubility, modifying metabolisms, and target specificity, prolonged circulation, enhanced permeation.
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