Osteoporosis in the European Union: a compendium of country-specific reports
Axel Svedbom,E Hernlund,M Ivergard,Juliet E. Compston,Cyrus Cooper,Cyrus Cooper,J Stenmark,Eugene V. McCloskey,Eugene V. McCloskey,Bengt Jönsson,John A. Kanis +10 more
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TLDR
In spite of the high cost of osteoporosis, a substantial treatment gap and projected increase of the economic burden driven by aging populations, the use of pharmacological prevention of osteeporosis has decreased in recent years, suggesting that a change in healthcare policy concerning the disease is warranted.Abstract:
This report describes epidemiology, burden, and treatment of osteoporosis in each of the 27 countries of the European Union (EU27). In 2010, 22 million women and 5.5 million men were estimated to have osteoporosis in the EU; and 3.5 million new fragility fractures were sustained, comprising 620,000 hip fractures, 520,000 vertebral fractures, 560,000 forearm fractures and 1,800,000 other fractures. The economic burden of incident and prior fragility fractures was estimated at € 37 billion. Previous and incident fractures also accounted for 1,180,000 quality-adjusted life years lost during 2010. The costs are expected to increase by 25 % in 2025. The majority of individuals who have sustained an osteoporosis-related fracture or who are at high risk of fracture are untreated and the number of patients on treatment is declining. The aim of this report was to characterize the burden of osteoporosis in each of the EU27 countries in 2010 and beyond. The data on fracture incidence and costs of fractures in the EU27 were taken from a concurrent publication in this journal (Osteoporosis in the European Union: Medical Management, Epidemiology and Economic Burden) and country specific information extracted. The clinical and economic burden of osteoporotic fractures in 2010 is given for each of the 27 countries of the EU. The costs are expected to increase on average by 25 % in 2025. The majority of individuals who have sustained an osteoporosis-related fracture or who are at high risk of fracture are untreated and the number of patients on treatment is declining. In spite of the high cost of osteoporosis, a substantial treatment gap and projected increase of the economic burden driven by aging populations, the use of pharmacological prevention of osteoporosis has decreased in recent years, suggesting that a change in healthcare policy concerning the disease is warranted.read more
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Bone scintigraphy for the diagnosis of the responsible level of osteoporotic vertebral compression fractures in percutaneous balloon kyphoplasty.
Toshiyuki Okazaki,Toshiyuki Okazaki,Hiroshi Nakagawa,Kenji Yagi,Hitoshi Hayase,Shinji Nagahiro,Koji Saito +6 more
TL;DR: It is shown that bone scintigraphy is very useful in diagnosing the proper level for BKP in addition to CT and MRI in patients with acute multi-level VCFs.
Journal ArticleDOI
Efeito da multiparidade sobre a densidade mineral óssea, avaliada por marcadores de remodelação óssea
TL;DR: Encontrou‐se que os fatores de risco independentes para a osteoporose na analise de regressao das multiparas sao a duracao da menopausa e o peso corporal menor ou igual a 65 kg.
Journal ArticleDOI
Cost-effectiveness of buffered soluble alendronate 70 mg effervescent tablet for the treatment of postmenopausal women with osteoporosis in Italy
Mickaël Hiligsmann,Stefania Maggi,Nicola Veronese,Luigi Sartori,Jean-Yves Reginster,Jean-Yves Reginster +5 more
TL;DR: This study suggests that buffered soluble ALN represents a cost-effective strategy compared with relevant alternative treatments for postmenopausal osteoporosis women in Italy aged 60 years and over.
Journal ArticleDOI
Real-world Management of Women with Postmenopausal Osteoporosis Treated with Denosumab: A Prospective Observational Study in the Czech Republic and Slovakia
Olga Růžičková,Zdenko Killinger,Petr Kasalický,Lisa Hamilton,Roman Tyl,Soňa Tomková,Lama Kalouche-Khalil +6 more
TL;DR: Baseline characteristics of patients receiving denosumab in the Czech Republic and Slovakia reflect the reimbursement criteria for this agent in each country, and the findings of this study in patients who are at high risk for fracture are consistent with the growing body of evidence demonstrating the effectiveness of denosUMab in real-world clinical practice.
Journal ArticleDOI
Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
Syuji Kurogi,Tomohisa Sekimoto,Taro Funamoto,Tomomi Ota,Shihoko Nakamura,Takuya Nagai,Mai Nakahara,Kumiko Yoshinobu,Kimi Araki,Masatake Araki,Etsuo Chosa +10 more
TL;DR: An efficient screening system to identify novel genes involved in bone metabolism using mutant mouse strains registered with the Exchangeable Gene Trap Clones (EGTC) database is developed and the gene trap lines identified as abnormal using this screening approach are highly likely to trap important genes for bone metabolism.
References
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A reference standard for the description of osteoporosis.
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TL;DR: This paper proposes that the reference standard should be based on bone mineral density (BMD) measurement made at the femoral neck with dual-energy X-ray absorptiometry (DXA), which has been the most extensively validated, and provides a gradient of fracture risk as high as or higher than that of many other techniques.
Journal ArticleDOI
Long-Term Risk of Osteoporotic Fracture in Malmö
John A. Kanis,Olof Johnell,Anders Odén,Ingemar Sernbo,Inga Redlund-Johnell,A. Dawson,C De Laet,Bengt Jönsson +7 more
TL;DR: It is concluded that fractures of the hip and spine carry higher risks than fractures at other sites, and that lifetime risks of fracture of the hips in particular have been underestimated.
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