Journal ArticleDOI
Overall survival is improved in mucinous adenocarcinoma of the colon.
John Hogan,John P. Burke,Georges Samaha,Eoghan Condon,David Waldron,Peter N. Faul,J. Calvin Coffey,J. Calvin Coffey +7 more
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TLDR
Histopathological evidence of mucinous adenocarcinoma in colon cancer is associated with improved outcomes and was associated with reduced risk of death on univariate analysis and multivariate analysis.Abstract:
Debate persists regarding the relationship between mucin expression and outcome in colon cancer. This arises due to discrepancy in the definition of mucinous adenocarcinoma and the combination of both colon and rectal cancers in analyses. This study examines the relationship between increased mucin production and outcomes in colon cancer. Cases were classified according to the World Health Organization classification of mucinous adenocarcinoma of the colon. Accordingly, tumors were categorized as either (a) mucinous adenocarcinoma of the colon (greater than 50 % of the extracellular matrix occupied by mucin) or (b) non-mucinous adenocarcinoma of the colon. Overall survival and disease-free survival were calculated. A stepwise Cox proportional hazards regression model was employed to determine the risk of death/disease recurrence. Kaplan–Meier estimates of overall survival and disease-free survival were plotted for each group and compared using a log-rank test. On univariate analysis, mucinous adenocarcinoma was associated with reduced risk of death (P = 0.01). On multivariate analysis, mucinous adenocarcinoma was also associated with reduced risk of death (hazard ratio (HR) 0.33, 95 % confidence interval (CI) 0.14–0.79, P = 0.01). Kaplan–Meier estimates confirmed improved rate of survival in the mucinous vs. non-mucinous group (P = 0.01). Mucinous adenocarcinoma did not affect disease-free survival (HR 0.75, 95 % CI 0.46–1.21, P = 0.22). A comparison of Kaplan–Meier estimates for systemic recurrence demonstrated significant increases in systemic recurrence in the group with no mucin production (P = 0.04) but not for locoregional recurrence (P = 0.24). Histopathological evidence of mucinous adenocarcinoma in colon cancer is associated with improved outcomes.read more
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Advances in the care of patients with mucinous colorectal cancer
TL;DR: The authors provide insight into advances that have been made in the care of patients with MC and the predictive implications of MC regarding responses to commonly used therapies for CRC, such as chemotherapy, radiotherapy and chemoradiotherapy, and the potential for, and severity of, metastasis are described.
Journal ArticleDOI
Mucinous Rectal Adenocarcinoma Is Associated with a Poor Response to Neoadjuvant Chemoradiotherapy: A Systematic Review and Meta-analysis
Niamh McCawley,Cillian Clancy,Brian P. O'Neill,Joseph Deasy,Deborah A. McNamara,John P. Burke +5 more
TL;DR: Mucinous rectal adenocarcinoma represents a biomarker for poor response to preoperative chemoradiotherapy and is an adverse prognostic indicator.
Journal ArticleDOI
Lymphovascular invasion: a comprehensive appraisal in colon and rectal adenocarcinoma.
John Hogan,Kah Hoong Chang,Gerald Duff,Georges Samaha,N.P. Kelly,Michael Burton,Emily Burton,John Calvin Coffey +7 more
TL;DR: Lymphovascular invasion positivity was associated with different patterns of disease recurrence in colon and rectal cancer and was a poor prognostic indicator in rectal adenocarcinoma only.
Journal ArticleDOI
Impact of histological subtype on the prognosis of patients undergoing surgery for colon cancer.
Fabio Bagante,Fabio Bagante,Gaya Spolverato,Eliza W. Beal,Katiuscha Merath,Qinyu Chen,Ozgur Akgul,Robert A. Anders,Timothy M. Pawlik +8 more
TL;DR: The effect of the histological subtype on the prognosis of patients undergoing surgery for colon cancer (CC) is not completely understood.
Journal ArticleDOI
Predictive value of mucinous histology in colon cancer: a population-based, propensity score matched analysis.
Rene Warschkow,Ignazio Tarantino,Felix J Hüttner,Bruno M. Schmied,Ulrich Güller,Markus K. Diener,Alexis Ulrich +6 more
TL;DR: In this population-based investigation, a mucinous histology did not negatively impact survival and the present study does not provide evidence to change treatment strategies in patients with mucinous adenocarcinoma of the colon.
References
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Journal ArticleDOI
World Health Organization classification of tumors.
Paul Kleihues,Leslie H. Sobin +1 more
TL;DR: World Health Organization Collaborating Center for International Histological Classification of Tu-mors, Armed Forces Institute of Pathology, Wash-ington, DC.
Journal ArticleDOI
Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial
Willem van Gijn,Carrie A. M. Marijnen,Iris D. Nagtegaal,Elma Meershoek-Klein Kranenbarg,Hein Putter,Theo Wiggers,Harm J. T. Rutten,Lars Påhlman,Bengt Glimelius,Cornelis J.H. van de Velde +9 more
TL;DR: Preoperative short-term radiotherapy significantly improved 10-year survival in patients with a negative circumferential margin and TNM stage III, and future staging techniques should offer possibilities to select patient groups for which the balance between benefits and side-effects will result in sufficiently large gains.
Journal ArticleDOI
Mucins and mucin binding proteins in colorectal cancer.
TL;DR: Colon cancer mucins have differences in both core carbohydrates and in peripheral carbohydrate structures that are being investigated as diagnostic and prognostic markers, and also as targets for cancer vaccines.
Journal Article
Patterns of recurrence after curative resection of carcinoma of the colon and rectum.
TL;DR: Patterns of recurrence based on the characteristics of the tumor may facilitate selection of the most appropriate adjuvant procedures, particularly those directed toward local or regional recurrence, or both, and also may guide efforts at early recognition ofRecurrence.