Journal ArticleDOI
Overexpression of transforming growth factor α in psoriatic epidermis
James T. Elder,Gary J. Fisher,Patricia B. Lindquist,Gregory L. Bennett,Mark R. Pittelkow,Robert J. Coffey,Larry Ellingsworth,Rik Derynck,John J. Voorhees +8 more
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TLDR
Psoriatic epidermal hyperplasia may involve increased expression of a keratinocyte mitogen (TGF-alpha) rather than deficient expression of an growth inhibitor (T GF-beta 1) in normal, uninvolved, and lesional psoriatic Epidermis.Abstract:
Transforming growth factor alpha (TGF-alpha) is produced by and required for the growth of epithelial cells and is angiogenic in vivo. Since epidermal hyperplasia and angiogenesis are hallmarks of psoriasis, TGF-alpha gene expression was analyzed in epidermal biopsies of normal and psoriatic skin. TGF-alpha messenger RNA and protein are much more abundant in lesional psoriatic epidermis than in normal-appearing skin of psoriatic patients or in normal epidermis. In contrast, messenger RNA levels of transforming growth factor beta 1 (TGF-beta 1), which inhibits epithelial cell growth, are not significantly different in normal, uninvolved, and lesional psoriatic epidermis. Thus, psoriatic epidermal hyperplasia may involve increased expression of a keratinocyte mitogen (TGF-alpha) rather than deficient expression of a growth inhibitor (TGF-beta 1).read more
Citations
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Epidermal growth factor-related peptides and their receptors in human malignancies
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Tyrosine kinase inhibition: an approach to drug development
Alexander Levitzki,Aviv Gazit +1 more
TL;DR: This article summarizes recent progress in the development of PTK inhibitors and demonstrates their potential use in the treatment of disease.
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Keratinocyte–Fibroblast Interactions in Wound Healing
TL;DR: This review focuses on the role of keratinocyte-fibroblast interactions in the wound-healing process and the phenotype of fibroblasts from different tissues or body sites becomes better defined, so as to understand their individual contribution in wound healing in more detail and possibly explain different clinical outcomes.
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Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.
Rachel Grossman,James G. Krueger,Debra Yourish,Angela Granelli-Piperno,Daniel P. Murphy,Lester T. May,Thomas S. Kupper,Pravinkumar B. Sehgal,Alice B. Gottlieb +8 more
TL;DR: Interleukin 6 could directly contribute to the epidermal hyperplasia seen in psoriatic epithelium as well as affect the function of dermal inflammatory cells.
References
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TL;DR: A technique for conveniently radiolabeling DNA restriction endonuclease fragments to high specific activity is described, and these "oligolabeled" DNA fragments serve as efficient probes in filter hybridization experiments.
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
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