P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in Cancer.
Dahong Yao,Chenyang Li,Muhammad Shahid Riaz Rajoka,Zhendan He,Jian Huang,Jin-Hui Wang,Jin Zhang +6 more
TLDR
An overview of essential roles that PAK1 plays in cancer, including its structure and autoactivation mechanism, its crucial function from onset to progression to metastasis, metabolism, immune escape and even drug resistance in cancer; endogenous regulators; and cancer-related pathways is provided.Abstract:
The p21-Activated kinase 1 (PAK1), a member of serine-threonine kinases family, was initially identified as an interactor of the Rho GTPases RAC1 and CDC42, which affect a wide range of processes associated with cell motility, survival, metabolism, cell cycle, proliferation, transformation, stress, inflammation, and gene expression. Recently, the PAK1 has emerged as a potential therapeutic target in cancer due to its role in many oncogenic signaling pathways. Many PAK1 inhibitors have been developed as potential preclinical agents for cancer therapy. Here, we provide an overview of essential roles that PAK1 plays in cancer, including its structure and autoactivation mechanism, its crucial function from onset to progression to metastasis, metabolism, immune escape and even drug resistance in cancer; endogenous regulators; and cancer-related pathways. We also summarize the reported PAK1 small-molecule inhibitors based on their structure types and their potential application in cancer. In addition, we provide overviews on current progress and future challenges of PAK1 in cancer, hoping to provide new ideas for the diagnosis and treatment of cancer.read more
Citations
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Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy.
TL;DR: In this paper, a review on how HDAC inhibitors regulate the expression of coding and non-coding genes with specific emphasis on their anti-cancer potential is presented, where several combinations of HAC inhibitors along with DNA methyl transferase inhibitors and HATs are in clinical trials.
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RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway
Deyu Zhang,Qiwei Jiang,Xiangwei Ge,Yanzhu Shi,Tianxing Ye,Yue Mi,Tian Xie,Qihong Li,Qinong Ye +8 more
TL;DR: In this paper, the authors identify an important role of ras homolog family member V (RHOV) in lung adenocarcinoma (LUAD) metastasis using a combination of bioinformatic analysis and functional experiments.
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The Role of p21-Activated Kinases in Cancer and Beyond: Where Are We Heading?
Hui Liu,Kangdong Liu,Zigang Dong +2 more
TL;DR: The p21-activated kinases (PAKs), downstream effectors of Ras-related Rho GTPase Cdc42 and Rac, are serine/threonine kinases that participate in various cellular processes, including growth, apoptosis, mitosis, immune response, motility, inflammation, and gene expression.
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Dysregulated expression and functions of microRNA-330 in cancers: A potential therapeutic target
TL;DR: In this paper , a review comprehensively explained miR-330-3p and miR330-5p role in development of cancers, while highlighting their downstream target genes and upstream regulators as well as possible therapeutic strategies.
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Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling
Kinjal Shah,Julhash U. Kazi +1 more
TL;DR: An overview of how protein phosphorylation controls WNT/β-catenin signaling, particularly in human cancer, is provided.
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