Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.
Roel Nusse,Hans Clevers +1 more
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TLDR
The core Wnt/β-catenin signaling pathway is described, how it controls stem cells, and contributes to disease, and strategies for Wnt-based therapies are discussed.About:
This article is published in Cell.The article was published on 2017-06-01 and is currently open access. It has received 2663 citations till now. The article focuses on the topics: Wnt signaling pathway & Stem cell.read more
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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.
Yixiao Feng,Yixiao Feng,Mia Spezia,Shifeng Huang,Shifeng Huang,Chengfu Yuan,Chengfu Yuan,Zongyue Zeng,Zongyue Zeng,Linghuan Zhang,Linghuan Zhang,Xiaojuan Ji,Xiaojuan Ji,Wei Liu,Wei Liu,Bo Huang,Bo Huang,Bo Huang,Wenping Luo,Wenping Luo,Bo Liu,Bo Liu,Yan Lei,Yan Lei,Scott Du,Akhila Vuppalapati,Hue H. Luu,Rex C. Haydon,Tong-Chuan He,Guosheng Ren +29 more
TL;DR: Emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer, especially for triple-negative breast cancer.
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Tales from the crypt: new insights into intestinal stem cells.
TL;DR: How the niche protects and instructs intestinal stem cells is investigated, which processes drive differentiation of mature cells and how imbalance in key signalling pathways can cause human disease are explored.
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Wnt signaling in development and tissue homeostasis.
TL;DR: An overview of Wnt-β-catenin signaling highlighting its key functions during development and adult tissue homeostasis is provided.
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Targeting the Wnt/β-catenin signaling pathway in cancer.
TL;DR: This scoping review aims at outlining the latest progress on the current approaches and perspectives of Wnt/β-catenin signaling pathway targeted therapy in various cancer types and better understanding of the updates on the inhibitors, antagonists and activators rationalizes innovative strategies for personalized cancer treatment.
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Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells.
Cornelia Kröger,Alexander Afeyan,Alexander Afeyan,Jasmin Mraz,Jasmin Mraz,Elinor Ng Eaton,Ferenc Reinhardt,Yevgenia L. Khodor,Prathapan Thiru,Brian Bierie,Xin Ye,Xin Ye,Christopher B. Burge,Robert A. Weinberg +13 more
TL;DR: It is demonstrated that tumorigenicity depends on individual cells residing in this E/M hybrid state and cannot be phenocopied by mixing two cell populations that reside stably at the two ends of the spectrum, Hence, residence in a specific intermediate state along the E–M spectrum rather than phenotypic plasticity appears critical to the expression of tumor-initiating capacity.
References
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Toshiro Sato,Robert G.J. Vries,Hugo J. Snippert,Marc van de Wetering,Nick Barker,Daniel E. Stange,Johan H. van Es,Arie Abo,Pekka Kujala,Peter J. Peters,Hans Clevers +10 more
TL;DR: It is concluded that intestinal cryptvillus units are self-organizing structures, which can be built from a single stem cell in the absence of a non-epithelial cellular niche.
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Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.
Journal ArticleDOI
Wnt/β-catenin signaling and disease.
Hans Clevers,Roel Nusse +1 more
TL;DR: An update of the core Wnt/β-catenin signaling pathway is provided, how its various components contribute to disease, and outstanding questions to be addressed in the future are discussed.
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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.