Journal ArticleDOI
Parameter optimization of a laser-induced fluorescence system for in vivo screening of oral cancer
V. K. Unnikrishnan,Rajesh Nayak,R. Bernard,K. Jeena Priya,Ajeetkumar Patil,J. Ebenezer,Keerthilatha M. Pai,Sajan D. George,V. B. Kartha,C. Santhosh +9 more
TLDR
In this paper, the effect of various experimental parameters such as source stability, area of exposure, and angular/distance dependence of a fiber probe, which is used for the fluorescence measurements, from the specimen surface on the spectra.Abstract:
Despite the advances in optical technologies for early detection of cancer, routine clinical applications are still not standardized. Among several optical methods, laser-induced fluorescence is a more matured and well understood technique. Still due care has to be taken about various factors to avoid erroneous results. The authors have carried out a systematic study on the effect of the various experimental parameters such as source stability, area of exposure, and angular/distance dependence of a fiber probe, which is used for the fluorescence measurements, from the specimen surface on the spectra. Investigations are carried out on both idealistic cases as well as on tissue surface. The details of the optimization of the parameters are presented and discussed in this paper.read more
Citations
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Journal ArticleDOI
Hybrid LIBS-Raman-LIF systems for multi-modal spectroscopic applications: a topical review
TL;DR: In this paper, the importance of hyphenating different laser-based techniques such as laser-induced breakdown spectroscopy (LIBS), Raman Spectroscopy, and LIFS was discussed.
Journal ArticleDOI
A review on human body fluids for the diagnosis of viral infections: scope for rapid detection of COVID-19.
Sphurti S Adigal,Nidheesh V Rayaroth,Reena V John,Keerthilatha M. Pai,Sulatha Bhandari,Aswini Kumar Mohapatra,Jijo Lukose,Ajeetkumar Patil,Aseefhali Bankapur,Santhosh Chidangil +9 more
TL;DR: In this paper, a brief review strongly recommends the application of saliva/tears and exhaled breath as clinical samples using technics such as highperformance liquid chromatography-laser-induced fluorescence, photoacoustic spectroscopy, and e-Nose, respectively, for the fast diagnosis of viral infections.
Book ChapterDOI
Optical Techniques: Investigations in Oral Cancers
Piyush Kumar,C. Murali Krishna +1 more
TL;DR: The chapter begins with discussion on scope of optical techniques and basic principles of these techniques, followed by a brief discussion of multivariate statistical tools which play a major role in data analysis, and provides an overview on explorations of Optical techniques in oral cancer screening/diagnosis.
Journal ArticleDOI
Optical characterizations of nanoporous anodic alumina for thickness measurements using interference oscillations
K.S. Choudhari,Suresh D. Kulkarni,V. K. Unnikrishnan,Rajesh Kumar Sinha,C. Santhosh,Sajan D. George +5 more
TL;DR: In this paper, three optical characterizations, namely, Ultraviolet-Visible-Near Infrared (UV-VIS-NIR), Photoluminescence (PL), and Reflective interference spectra were used to measure NAA thickness.
Journal ArticleDOI
Non-invasive in vivo screening of oral malignancy using laser-induced fluorescence based system
Ajeetkumar Patil,V. K. Unnikrishnan,Ravikiran Ongole,Keerthilatha M. Pai,V. B. Kartha,Santhosh Chidangil +5 more
TL;DR: This research presents a new approach to biophotonics that combines laser-spot assisted, 3D image analysis and 3D numerical simulation to solve the mystery of why light is attracted to certain materials.
References
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Journal ArticleDOI
In Vivo Fluorescence Spectroscopy and Imaging for Oncological Applications
TL;DR: This poster presents a probabilistic procedure to characterize the response of the immune cells of the central nervous system to laser-spot assisted chemoreception and excites the immune system.
Journal ArticleDOI
Critical Evaluation of Diagnostic Aids for the Detection of Oral Cancer
TL;DR: This manuscript systematically and critically examines the literature associated with current oral cancer screening and case-finding aids or adjuncts such as toluidine blue, brush cytology, tissue reflectance and autofluorescence and poses several questions for clinicians and scientists to consider in the evaluation of current and future studies of oral cancer detection and diagnosis.
Journal ArticleDOI
Simple device for the direct visualization of oral-cavity tissue fluorescence
Pierre Lane,Terence J. Gilhuly,Peter D. Whitehead,Haishan Zeng,Catherine F. Poh,Samson Ng,P. Michele Williams,Lewei Zhang,Miriam P. Rosin,Calum MacAulay +9 more
TL;DR: A robust, field-of-view device that facilitates the direct visualization of oral-cavity fluorescence for the detection of high-risk precancerous and early cancerous lesions and is envisaged as a suitable adjunct for oral cancer screening, biopsy guidance, and margin delineation.
Journal ArticleDOI
Spectroscopic detection and evaluation of morphologic and biochemical changes in early human oral carcinoma.
Markus G. Müller,Tulio A. Valdez,Irene Georgakoudi,Vadim Backman,Cesar Fuentes,Sadru Kabani,Nora Laver,Zimmern Wang,Charles W. Boone,Ramachandra R. Dasari,Stanley M. Shapshay,Michael S. Feld +11 more
TL;DR: The current study correlated early biochemical and histologic changes in oral tissue with spectral features in fluorescence, reflectance, and light scattering spectra acquired in vivo to diagnose early stages of oral malignancies.
Journal ArticleDOI
The status of in vivo autofluorescence spectroscopy and imaging for oral oncology
TL;DR: It is hoped that from the studies performed so far whether autofluorescence spectroscopy and imaging are helpful in the diagnosis of lesions of the oral mucosa, and if this is the case: for which clinical questions they are suitable.