Parotid gland biopsy compared with labial biopsy in the diagnosis of patients with primary Sjogren's syndrome
J. Pijpe,Warner Kalk,J.E. van der Wal,Arjan Vissink,Philippus Kluin,Jan L. N. Roodenburg,Hendrika Bootsma,Cornelis Kallenberg,Frederik Spijkervet +8 more
TLDR
A parotid biopsy has a diagnostic potential comparable with that of a labial biopsy in the diagnosis of pSS, and may be associated with less morbidity.Abstract:
Objective. To assess the value of the parotid biopsy as a diagnostic tool for primary Sjogren's syndrome ( pSS), and to compare the parotid biopsy and the labial biopsy with regard to diagnostic value and biopsy-related morbidity. Methods. In 15 consecutive patients with pSS and 20 controls, the parotid biopsy was assessed as a diagnostic tool based on the presence of lymphocytic foci, benign lymphoepithelial lesions and lymphoid follicles. These new histological criteria were compared with established diagnostic criteria for the labial biopsy in 35 consecutive patients suspected for pSS who underwent simultaneous biopsies from both sites. In addition, both biopsies were compared for morbidity. Results. The first analysis revealed a focus score of >= 1 or lymphocytic infiltrates ( not fulfilling the criterion of a focus score of 1) combined with benign lymphoepithelial lesions as diagnostic criteria for pSS. When comparing the parotid biopsy with the labial biopsy sensitivity and specificity were comparable (sensitivity 78%, specificity 86%). Level of pain was comparable and no loss of motor function was observed. No permanent sensory loss was observed after parotid biopsy, while labial biopsy led to permanent sensory loss in 6% of the patients. Malignant lymphoma was detected in one parotid biopsy by chance, without involvement of the labial salivary gland. Conclusion. A parotid biopsy has a diagnostic potential comparable with that of a labial biopsy in the diagnosis of pSS, and may be associated with less morbidity.read more
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Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjögren syndrome
Manon E. Wildenberg,Jojanneke M. C. Welzen-Coppens,C.G. van Helden-Meeuwsen,Hendrika Bootsma,Arjan Vissink,N. van Rooijen,J. P. van de Merwe,Hemmo A. Drexhage,Marjan A. Versnel +8 more
TL;DR: Mature monocytes are increased in pSjS and patient and mouse data support a model where this mature monocyte subset migrates to the salivary glands and develops into DCs.
Journal ArticleDOI
A comparison of diagnostic tools for Sjögren syndrome, with emphasis on sialography, histopathology, and ultrasonography
TL;DR: Ultrasonography can be used as a diagnostic tool for SS, with its advantage of noninvasiveness and ease of use.
Journal ArticleDOI
Immunopathologic differences of Sjögren's syndrome versus sicca syndrome in HCV and HIV infection.
TL;DR: Besides sicca complaints, the various disorders may also share a number of systemic extra-glandular features and the possible development of mucosa-associated lymphoid tissue lymphomas, which represents the final result of an antigen-driven chronic stimulation of B lymphocytes.
Journal ArticleDOI
Clinical and laboratory profiles of primary Sjogren's syndrome in a Chinese population: a retrospective analysis of 315 patients
TL;DR: To assess the clinical and laboratory features of primary Sjogren's syndrome (pSS) in a large teaching hospital in China, the objective was to establish a database of patients diagnosed with pSS in China and establish a standard of care.
Journal ArticleDOI
Salivary Gland Biopsy for Sjogren's Syndrome
TL;DR: This article focuses on the main techniques used for taking labial and parotid salivary gland biopsies in the diagnostic workup of SS with respect to their advantages, their postoperative complications, and their usefulness for diagnostic procedures, monitoring disease progression, and treatment evaluation.
References
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Sjögren's syndrome
TL;DR: It is suggested that the term Sjögren's syndrome be used to describe one subset of patients with sicca symptoms who exhibit particular major histocompatibility complex antigens, the presence of T cell lymphoid infiltrates on glandular biopsy, and specific autoantibodies in their sera.
Journal ArticleDOI
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Sjögren's syndrome. Proposed criteria for classification
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