Parotid gland biopsy compared with labial biopsy in the diagnosis of patients with primary Sjogren's syndrome
J. Pijpe,Warner Kalk,J.E. van der Wal,Arjan Vissink,Philippus Kluin,Jan L. N. Roodenburg,Hendrika Bootsma,Cornelis Kallenberg,Frederik Spijkervet +8 more
TLDR
A parotid biopsy has a diagnostic potential comparable with that of a labial biopsy in the diagnosis of pSS, and may be associated with less morbidity.Abstract:
Objective. To assess the value of the parotid biopsy as a diagnostic tool for primary Sjogren's syndrome ( pSS), and to compare the parotid biopsy and the labial biopsy with regard to diagnostic value and biopsy-related morbidity. Methods. In 15 consecutive patients with pSS and 20 controls, the parotid biopsy was assessed as a diagnostic tool based on the presence of lymphocytic foci, benign lymphoepithelial lesions and lymphoid follicles. These new histological criteria were compared with established diagnostic criteria for the labial biopsy in 35 consecutive patients suspected for pSS who underwent simultaneous biopsies from both sites. In addition, both biopsies were compared for morbidity. Results. The first analysis revealed a focus score of >= 1 or lymphocytic infiltrates ( not fulfilling the criterion of a focus score of 1) combined with benign lymphoepithelial lesions as diagnostic criteria for pSS. When comparing the parotid biopsy with the labial biopsy sensitivity and specificity were comparable (sensitivity 78%, specificity 86%). Level of pain was comparable and no loss of motor function was observed. No permanent sensory loss was observed after parotid biopsy, while labial biopsy led to permanent sensory loss in 6% of the patients. Malignant lymphoma was detected in one parotid biopsy by chance, without involvement of the labial salivary gland. Conclusion. A parotid biopsy has a diagnostic potential comparable with that of a labial biopsy in the diagnosis of pSS, and may be associated with less morbidity.read more
Citations
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Reciprocal relation between GADD153 and Del-1 in regulation of salivary gland inflammation in Sjögren syndrome
TL;DR: The hypothesis that Sjögren's syndrome (SS) is associated with increased salivary gland expression of GADD153 and increased leukocyte infiltration in association with decreased Del-1 thereby contributing to inflammation and cell death is tested.
Journal ArticleDOI
Ig Gene Analysis Reveals Altered Selective Pressures on Ig-Producing Cells in Parotid Glands of Primary Sjögren’s Syndrome Patients
Nishath Hamza,Uri Hershberg,Cees G. M. Kallenberg,Arjan Vissink,Frederik Spijkervet,Hendrika Bootsma,Frans G. M. Kroese,Nicolaas A. Bos +7 more
TL;DR: It is speculated that B cell hyperproliferation within parotid glands of primary Sjögren’s syndrome patients may result from Ag-independent interactions such as that between glycosylated B cell receptors and lectins within the microenvironment rather than (auto)antigen-specific stimulation.
Journal ArticleDOI
Scoring hypoechogenic areas in one parotid and one submandibular gland increases feasibility of ultrasound in primary Sjögren's syndrome.
Esther Mossel,Suzanne Arends,Jolien F van Nimwegen,Konstantina Delli,Alja J Stel,Frans G. M. Kroese,Fred K L Spijkervet,Arjan Vissink,Hendrika Bootsma +8 more
TL;DR: SUS examination of parotid and submandibular glands on one side is sufficient to predict classification of patients according to the ACR-EULAR criteria, and only hypoechogenic areas can be scored to increase feasibility of sUS in outpatient clinics worldwide.
Journal ArticleDOI
Memory B-cell aggregates in skin biopsy are diagnostic for primary Sjögren’s syndrome
Anne-Marie Roguedas,Jacques-Olivier Pers,Gilles Lemasson,Valérie Devauchelle,Gabriel J. Tobón,Alain Saraux,Laurent Misery,Pierre Youinou +7 more
TL;DR: Findings strongly suggest that skin biopsies warrant inclusion into the routine clinical care of patients suspected of suffering from primary SS, and B cell infiltrates were identified in patients' skin infiltrates, so that their presence might be a clue to the diagnosis of primary SS.
Journal ArticleDOI
Diagnostic Approaches to Sjögren's syndrome: a Literature Review and Own Clinical Experience.
TL;DR: The purpose of present paper is to critically address the recent advances on diagnostic procedures of Sjögren's syndrome, taking into account the attained local and systemic features of the disease.
References
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