Parotid gland biopsy compared with labial biopsy in the diagnosis of patients with primary Sjogren's syndrome
J. Pijpe,Warner Kalk,J.E. van der Wal,Arjan Vissink,Philippus Kluin,Jan L. N. Roodenburg,Hendrika Bootsma,Cornelis Kallenberg,Frederik Spijkervet +8 more
TLDR
A parotid biopsy has a diagnostic potential comparable with that of a labial biopsy in the diagnosis of pSS, and may be associated with less morbidity.Abstract:
Objective. To assess the value of the parotid biopsy as a diagnostic tool for primary Sjogren's syndrome ( pSS), and to compare the parotid biopsy and the labial biopsy with regard to diagnostic value and biopsy-related morbidity. Methods. In 15 consecutive patients with pSS and 20 controls, the parotid biopsy was assessed as a diagnostic tool based on the presence of lymphocytic foci, benign lymphoepithelial lesions and lymphoid follicles. These new histological criteria were compared with established diagnostic criteria for the labial biopsy in 35 consecutive patients suspected for pSS who underwent simultaneous biopsies from both sites. In addition, both biopsies were compared for morbidity. Results. The first analysis revealed a focus score of >= 1 or lymphocytic infiltrates ( not fulfilling the criterion of a focus score of 1) combined with benign lymphoepithelial lesions as diagnostic criteria for pSS. When comparing the parotid biopsy with the labial biopsy sensitivity and specificity were comparable (sensitivity 78%, specificity 86%). Level of pain was comparable and no loss of motor function was observed. No permanent sensory loss was observed after parotid biopsy, while labial biopsy led to permanent sensory loss in 6% of the patients. Malignant lymphoma was detected in one parotid biopsy by chance, without involvement of the labial salivary gland. Conclusion. A parotid biopsy has a diagnostic potential comparable with that of a labial biopsy in the diagnosis of pSS, and may be associated with less morbidity.read more
Citations
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The diagnostic utility of biopsies from the submandibular and
Masafumi Moriyama,Sachiko Furukawa,Shintaro Kawano,Yuichi Goto,Tamotsu Kiyoshima,Akihiko Tanaka,Takashi Maehara,Miho Ohta,Seiji Nakamura +8 more
TL;DR: In this paper, the diagnostic utility of submandibular gland (SMG) and labial salivary gland (LSG) biopsies in IgG4-DS was examined.
Journal ArticleDOI
Clinical practice guideline for Sjögren's syndrome 2017.
Takayuki Sumida,Naoto Azuma,Masafumi Moriyama,Hiroyuki Takahashi,Hiromitsu Asashima,Fumika Honda,Saori Abe,Yuko Ono,Yuko Ono,Tomoya Hirota,Shintaro Hirata,Shintaro Hirata,Yoshiya Tanaka,Toshimasa Shimizu,Hideki Nakamura,Atsushi Kawakami,Hajime Sano,Yoko Ogawa,Kazuo Tsubota,Koufuchi Ryo,Ichiro Saito,Akihiko Tanaka,Seiji Nakamura,Etsuko Takamura,Masao Tanaka,Katsuya Suzuki,Tsutomu Takeuchi,Noriyuki Yamakawa,Tsuneyo Mimori,Akiko Ohta,Susumu Nishiyama,Toshio Yoshihara,Yasunori Suzuki,Mitsuhiro Kawano,Minako Tomiita,Hiroto Tsuboi +35 more
TL;DR: The CPG for SS 2017 should contribute to improvement and standardization of diagnosis and treatment of SS.
Journal ArticleDOI
Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren's syndrome.
Jingxiu Xuan,Jingxiu Xuan,Long Shen,Kishore Malyavantham,Oleh Pankewycz,Julian L. Ambrus,Lakshmanan Suresh +6 more
TL;DR: SS may be an organ specific disease with early inflammation occurring in submandibular and lacrimal glands, followed by the parotid, according to a cross sectional study of inflammatory changes in mouse models of SS at various ages.
Journal ArticleDOI
Stereotypic rheumatoid factors that are frequently expressed in mucosa-associated lymphoid tissue-type lymphomas are rare in the labial salivary glands of patients with Sjögren's syndrome.
Richard J. Bende,Linda M. Slot,Robbert Hoogeboom,Thera A. M. Wormhoudt,Akanbi O. Adeoye,Jeroen E. J. Guikema,Carel J. M. van Noesel +6 more
TL;DR: This study was undertaken to investigate whether in the inflamed salivary glands of patients with SS, a similar RF‐biased Ig repertoire is present.
Journal ArticleDOI
Parotid Gland Biopsy, the Alternative Way to Diagnose Sjogren Syndrome
TL;DR: The main techniques for taking labial and parotid salivary gland biopsies are described with respect to their advantages, postoperative complications, and usefulness for diagnostic procedures, monitoring disease progression, and evaluation of treatment.
References
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Journal ArticleDOI
Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group
Claudio Vitali,Stefano Bombardieri,Roland Jonsson,Haralampos M. Moutsopoulos,E L Alexander,Steven E. Carsons,Troy E. Daniels,P C Fox,Robert I. Fox,Stuart S. Kassan,S R Pillemer,Norman Talal,M H Weisman +12 more
TL;DR: These classification criteria for Sjögren's syndrome have been re-examined by consensus group members, who have introduced some modifications, more clearly defined the rules for classifying patients with primary or secondary SS, and provided more precise exclusion criteria.
Journal ArticleDOI
World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997.
Nancy L. Harris,Elaine S. Jaffe,Jacques Diebold,G. Flandrin,H. Konrad Muller-Hermelink,James W. Vardiman,T. Andrew Lister,Clara D. Bloomfield +7 more
TL;DR: The experience of developing the WHO Classification has produced a new and exciting degree of cooperation and communication between oncologists and pathologists from around the world, which should facilitate progress in the understanding and treatment of hematologic malignancies.
Journal ArticleDOI
Sjögren's syndrome
TL;DR: It is suggested that the term Sjögren's syndrome be used to describe one subset of patients with sicca symptoms who exhibit particular major histocompatibility complex antigens, the presence of T cell lymphoid infiltrates on glandular biopsy, and specific autoantibodies in their sera.
Journal ArticleDOI
Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial
D McCarey,Iain B. McInnes,Rajan Madhok,R Hampson,Olga Scherbakova,Ian Ford,Hilary A Capell,Naveed Sattar +7 more
TL;DR: These data show that statins can mediate modest but clinically apparent anti-inflammatory effects with modification of vascular risk factors in the context of high-grade autoimmune inflammation.
Journal ArticleDOI
Sjögren's syndrome. Proposed criteria for classification
TL;DR: The clinical and laboratory features of patients referred for evaluation of sicca symptoms are reviewed, and the need for care in choosing the site for minor salivary gland biopsy is emphasized, and histologic features that aid in the evaluation of these biopsy specimens are described.
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