Parotid gland biopsy compared with labial biopsy in the diagnosis of patients with primary Sjogren's syndrome
J. Pijpe,Warner Kalk,J.E. van der Wal,Arjan Vissink,Philippus Kluin,Jan L. N. Roodenburg,Hendrika Bootsma,Cornelis Kallenberg,Frederik Spijkervet +8 more
TLDR
A parotid biopsy has a diagnostic potential comparable with that of a labial biopsy in the diagnosis of pSS, and may be associated with less morbidity.Abstract:
Objective. To assess the value of the parotid biopsy as a diagnostic tool for primary Sjogren's syndrome ( pSS), and to compare the parotid biopsy and the labial biopsy with regard to diagnostic value and biopsy-related morbidity. Methods. In 15 consecutive patients with pSS and 20 controls, the parotid biopsy was assessed as a diagnostic tool based on the presence of lymphocytic foci, benign lymphoepithelial lesions and lymphoid follicles. These new histological criteria were compared with established diagnostic criteria for the labial biopsy in 35 consecutive patients suspected for pSS who underwent simultaneous biopsies from both sites. In addition, both biopsies were compared for morbidity. Results. The first analysis revealed a focus score of >= 1 or lymphocytic infiltrates ( not fulfilling the criterion of a focus score of 1) combined with benign lymphoepithelial lesions as diagnostic criteria for pSS. When comparing the parotid biopsy with the labial biopsy sensitivity and specificity were comparable (sensitivity 78%, specificity 86%). Level of pain was comparable and no loss of motor function was observed. No permanent sensory loss was observed after parotid biopsy, while labial biopsy led to permanent sensory loss in 6% of the patients. Malignant lymphoma was detected in one parotid biopsy by chance, without involvement of the labial salivary gland. Conclusion. A parotid biopsy has a diagnostic potential comparable with that of a labial biopsy in the diagnosis of pSS, and may be associated with less morbidity.read more
Citations
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Neurological adverse events related to lip biopsy in patients suspicious for Sjögren’s syndrome: a systematic review and prevalence meta-analysis
Pablo Ignacio Varela Centelles,Mariña Sánchez-Sánchez,Julián Costa-Bouzas,Juan M. Seoane-Romero,Juan Seoane,Bahi Takkouche +5 more
TL;DR: It is concluded that the minimally invasive lip biopsy technique for SS diagnosis induces fewer permanent neurological complications than conventional approaches with large linear incisions in the lower lip.
Journal ArticleDOI
The parotid gland connection: ultrasound and biopsies in primary Sjögren’s syndrome
Esther Mossel,Konstantina Delli,Jolien F van Nimwegen,Alja J Stel,Erlin A. Haacke,Frans G. M. Kroese,Fred K L Spijkervet,Arjan Vissink,Suzanne Arends,Hendrika Bootsma +9 more
TL;DR: This study was the first that directly compared the validity of ultrasound of major salivary glands (sUS) with parotid gland biopsy outcome and showed that the agreement between sUS andParotid as well as labial gland biopsies was good but was slightly higher for the former.
Journal ArticleDOI
Apport de l’échographie des glandes salivaires dans la prise en charge du syndrome de Sjögren : où en sommes-nous ?
TL;DR: Salivary gland ultrasonography is a simple, noninvasive and inexpensive procedure, which provides valuable information for the diagnosis of primary Sjogren's syndrome (pSS) as mentioned in this paper.
Journal ArticleDOI
Frequency of complications and usefulness of the minor salivary gland biopsy.
María Lida Santiago,Maria Renata Seisdedos,Rodrigo García Salinas,Anastasia Secco,Lucila Marino Claverie,Lorena Techera,Lorena Takashima,Pedro Aicardi,Marco Antonio Sandi Rosales,Elizabeth Knobel,Sebastián Magri,Antonio Catalán Pellet +11 more
TL;DR: Minor salivary gland biopsy has very low frequency of medium term and acute complications and it has high usefulness.
Journal ArticleDOI
Pathogenetic Mechanisms Implicated in Sjögren's Syndrome Lymphomagenesis: A Review of the Literature.
TL;DR: Sjögren’s Syndrome is a chronic autoimmune disorder characterized by focal mononuclear cell infiltrates that surround the ducts of the exocrine glands, impairing the function of their secretory units, leading to increased morbidity and mortality rates.
References
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