PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
Barry L. Taylor,Igor B. Zhulin +1 more
Reads0
Chats0
TLDR
PAS domains are newly recognized signaling domains that are widely distributed in proteins from members of the Archaea and Bacteria and from fungi, plants, insects, and vertebrates that function as input modules in proteins that sense oxygen, redox potential, light, and some other stimuli.Abstract:
PAS domains are newly recognized signaling domains that are widely distributed in proteins from members of the Archaea and Bacteria and from fungi, plants, insects, and vertebrates. They function as input modules in proteins that sense oxygen, redox potential, light, and some other stimuli. Specificity in sensing arises, in part, from different cofactors that may be associated with the PAS fold. Transduction of redox signals may be a common mechanistic theme in many different PAS domains. PAS proteins are always located intracellularly but may monitor the external as well as the internal environment. One way in which prokaryotic PAS proteins sense the environment is by detecting changes in the electron transport system. This serves as an early warning system for any reduction in cellular energy levels. Human PAS proteins include hypoxia-inducible factors and voltage-sensitive ion channels; other PAS proteins are integral components of circadian clocks. Although PAS domains were only recently identified, the signaling functions with which they are associated have long been recognized as fundamental properties of living cells.read more
Citations
More filters
Journal ArticleDOI
Two-component signal transduction
TL;DR: Detailed analyses of a relatively small number of representative proteins provide a foundation for understanding this large family of signaling proteins, which consists of two conserved components, a histidine protein kinase and a response regulator protein.
Journal ArticleDOI
Acetylation of Histones and Transcription-Related Factors
TL;DR: This work detail these known factor acetyltransferase (FAT) substrates and the demonstrated or potential roles of their acetylation in transcriptional processes.
Journal ArticleDOI
Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.
Michael S. Denison,Scott R. Nagy +1 more
TL;DR: Evidence for the structural promiscuity of AhR ligand binding is described and the current state of knowledge with regards to the activation of the AhR signaling pathway by naturally occurring exogenous and endogenous ligands is discussed.
Journal ArticleDOI
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
TL;DR: HIF-1 appears to play a key role in the pathophysiology of cancer, cardiovascular disease, and chronic lung disease, which represent the major causes of mortality among industrialized societies.
Journal ArticleDOI
hERG potassium channels and cardiac arrhythmia
TL;DR: Insights gained from the crystal structures of other potassium channels have helped understanding of the block of hERG channels and the mechanisms of gating.
References
More filters
Journal ArticleDOI
Basic Local Alignment Search Tool
TL;DR: A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP) score.
Journal ArticleDOI
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
Stephen F. Altschul,Thomas L. Madden,Alejandro A. Schäffer,Jinghui Zhang,Zheng Zhang,Webb Miller,David J. Lipman +6 more
TL;DR: A new criterion for triggering the extension of word hits, combined with a new heuristic for generating gapped alignments, yields a gapped BLAST program that runs at approximately three times the speed of the original.
Journal ArticleDOI
Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions.
Takakazu Kaneko,Shusei Sato,Hirokazu Kotani,Ayako Tanaka,Erika Asamizu,Yasukazu Nakamura,Nobuyuki Miyajima,Makoto Hirosawa,Masahiro Sugiura,Shigemi Sasamoto,Takaharu Kimura,Tsutomu Hosouchi,Ai Matsuno,Akiko Muraki,Naomi Nakazaki,Kaoru Naruo,Satomi Okumura,Sayaka Shimpo,Chie Takeuchi,Tsuyuko Wada,Akiko Watanabe,Manabu Yamada,Miho Yasuda,Satoshi Tabata +23 more
TL;DR: The sequence determination of the entire genome of the Synechocystis sp.
Journal ArticleDOI
A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel
TL;DR: The finding that HERG encodes IKr channels provides a mechanistic link between certain forms of inherited and acquired LQT, and that an additional subunit may be required for drug sensitivity.
Journal ArticleDOI
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
Mark E. Curran,Igor Splawski,Katherine W. Timothy,Vincent Gm,Eric D. Green,Keating Mt,Keating Mt +6 more
TL;DR: In this article, the authors investigated patients with long QT syndrome (LQT), an inherited disorder causing sudden death from a ventricular tachyarrythmia, torsade de pointes.