Journal ArticleDOI
Passive Spatial Mapping of Inertial Cavitation During HIFU Exposure
Reads0
Chats0
TLDR
If cavitating regions can be directly correlated to increased tissue damage, this novel cavitation mapping technique could enable real-time HIFU treatment monitoring and be in good agreement with computational simulations and theoretical predictions.Abstract:
A novel method for mapping inertial cavitation activity during high-intensity focused ultrasound (HIFU) exposure is presented. Inertial cavitation has been previously shown to result in increased heat deposition and to be associated with broadband noise emissions that can be readily monitored using a passive receiver without interference from the main HIFU signal. In the present study, the signals received passively by each of 64 elements on a standard diagnostic array placed coaxially with the HIFU transducer are combined using time exposure acoustics to generate maps of inertially cavitating regions during HIFU exposure of an agar-based tissue-mimicking material. The technique is shown to be effective in localizing single-bubble activity, as well as contiguous and disjoint cavitating regions instigated by creating regions of lower cavitation threshold within the tissue phantom. The cavitation maps obtained experimentally are also found to be in good agreement with computational simulations and theoretical predictions. Unlike B-mode imaging, which requires interleaving with the HIFU pulse, passive array-based mapping of cavitation activity is possible during HIFU exposure. If cavitating regions can be directly correlated to increased tissue damage, this novel cavitation mapping technique could enable real-time HIFU treatment monitoring.read more
Citations
More filters
Journal ArticleDOI
A super-resolution ultrasound method for brain vascular mapping.
TL;DR: This method provides superior resolution to deep-tissue contrast ultrasound and has the potential to be extended to provide complete vascular network imaging in the brain.
Journal ArticleDOI
Ultrasound-Propelled Nanocups for Drug Delivery
James J. Kwan,Rachel Myers,Christian Coviello,Susan M. Graham,Apurva R. Shah,Eleanor Stride,Robert Carlisle,Constantin C. Coussios +7 more
TL;DR: Upon ultrasound exposure at frequencies and intensities achievable with existing diagnostic and therapeutic systems, nanocups initiate and sustain readily detectable cavitation activity for at least four times longer than existing microbubble constructs in an in vivo tumor model.
Journal ArticleDOI
Controlled Ultrasound-Induced Blood-Brain Barrier Disruption Using Passive Acoustic Emissions Monitoring
TL;DR: The results indicate that harmonic emissions can be a used to control focused ultrasound-induced BBB disruption and are promising for clinical translation of this technology.
Journal ArticleDOI
Spatiotemporal Monitoring of High-Intensity Focused Ultrasound Therapy with Passive Acoustic Mapping
Carl R. Jensen,Robert Ritchie,Miklós Gyöngy,James R. T. Collin,Tom Leslie,Constantin C. Coussios +5 more
TL;DR: Passive acoustic mapping significantly outperformed the conventional hyperecho technique as an ultrasound-based HIFU monitoring method, as both a detector of lesion occurrence and a method of mapping the position of ablated tissue.
Journal ArticleDOI
Thermometry and ablation monitoring with ultrasound
TL;DR: The current status of ultrasound thermometry and ablation monitoring is presented, with emphasis on the diverse approaches published in the literature and with an eye on which methods are closest to clinical reality.
References
More filters
Book
The Acoustic Bubble
TL;DR: In this article, the authors present a bibliographie (a la fin de chaque chapitre), and index reference record created on 2004-09-07, modified on 2016-08-08
Journal ArticleDOI
High-intensity focused ultrasound in the treatment of solid tumours.
TL;DR: For decades high-intensity focused ultrasound has promised to deliver the ultimate objective — truly non-invasive tumour ablation, but only now, with recent improvements in imaging, has this objective finally emerged as a real clinical possibility.
Journal ArticleDOI
Speed of Sound in Pure Water
V. A. Del Grosso,C. W. Mader +1 more
TL;DR: A sound speed equation of fifth order in temperature is fit with a standard deviation of 0.0028 m/sec to 148 observations between 0.001°C and 95.126°C on the T68 scale as discussed by the authors.
Journal ArticleDOI
Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU)
TL;DR: Models for how different types of cavitation activity can serve to accelerate tissue heating are presented, and results suggest that the bulk of the enhanced heating effect can be attributed to the absorption of broadband acoustic emissions generated by inertial cavitation.
Journal ArticleDOI
Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging
Shahram Vaezy,Xuegong Shi,Roy W. Martin,Emil Y. Chi,Peter I Nelson,Michael R. Bailey,Lawrence A. Crum +6 more
TL;DR: Real-time US imaging may provide a useful tool for image-guided HIFU therapy and was used in hemostasis of actively bleeding internal pelvic vessels, allowing targeting and monitoring of successful treatment.