Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.
Henk Granzier,Thomas C. Irving +1 more
TLDR
The passive tension-sarcomere length relation of rat cardiac muscle was investigated by studying passive (or not activated) single myocytes and trabeculae and the contribution of collagen, titin, microtubules, and intermediate filaments to tension and stiffness was investigated.About:
This article is published in Biophysical Journal.The article was published on 1995-03-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Obscurin & Titin.read more
Citations
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Journal ArticleDOI
Fiber types in mammalian skeletal muscles.
TL;DR: Mammalian skeletal muscle comprises different fiber types, whose identity is first established during embryonic development by intrinsic myogenic control mechanisms and is later modulated by neural and hormonal factors.
Journal ArticleDOI
Folding-Unfolding Transitions in Single Titin Molecules Characterized with Laser Tweezers
TL;DR: Scaling the molecular data up to sarcomeric dimensions reproduced many features of the passive force versus extension curve of muscle fibers, including force hysteresis arises from a difference between the unfolding and refolding kinetics of the molecule relative to the stretch and release rates in the experiments.
Journal ArticleDOI
Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity
TL;DR: The architecture of sequences in the A band region of titin suggests why thick filament structure is conserved among vertebrates and compares two elements that correlate with tissue stiffness that suggest that titin may act as two springs in series.
Journal ArticleDOI
Truncations of Titin Causing Dilated Cardiomyopathy
Daniel S. Herman,Lien Lam,Matthew R.G. Taylor,Libin Wang,Polakit Teekakirikul,Danos C. Christodoulou,Lauren Conner,Steven R. DePalma,Barbara McDonough,Elizabeth Sparks,Debbie Lin Teodorescu,Allison L. Cirino,Nicholas R. Banner,Dudley J. Pennell,Sharon L. Graw,Marco Merlo,Andrea Di Lenarda,Gianfranco Sinagra,J. Martijn Bos,Michael J. Ackerman,Richard N. Mitchell,Charles E. Murry,Neal K. Lakdawala,Carolyn Y. Ho,Paul J.R. Barton,Stuart A. Cook,Luisa Mestroni,Jonathan G. Seidman,Christine E. Seidman +28 more
TL;DR: Incorporation of sequencing approaches that detect TTN truncations into genetic testing for dilated cardiomyopathy should substantially increase test sensitivity, thereby allowing earlier diagnosis and therapeutic intervention for many patients with dilated heart disease.
Food security and food production systems
John R. Porter,Liyong Xie,Andrew J. Challinor,Kevern L. Cochrane,S. Mark Howden,Muhammad Iqbal,David B. Lobell,Maria I. Travasso,Netra Chhetri,Karen A. Garrett,John Ingram,Leslie Lipper,Nancy McCarthy,Justin M. McGrath,Daniel R. Smith,Philip K. Thornton,James E. M. Watson,Lewis H. Ziska +17 more
TL;DR: The questions for this chapter are how far climate and its change affect current food production systems and food security and the extent to which they will do so in the future.
References
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Book ChapterDOI
Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands.
TL;DR: The main thrust of the present chapter is to describe a FORTRAN program named "SPECS" in such a way that it can be readily used by the largest number of investigators possible.
Journal ArticleDOI
The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line.
TL;DR: Tin molecules appear as polar structures lacking over large regions repetitive epitopes over half-sarcomere lengths, and one physical end seems related to Z line anchorage, while the other may bind close to the M line.
Journal ArticleDOI
The cellular basis of the length-tension relation in cardiac muscle
David G. Allen,J.C. Kentish +1 more
TL;DR: There is good evidence that changes in the calcium supply to the myofibrils can account for the slow changes in tension that follow an alteration in length; there may also be rapid changes in calcium supply but this is less clearly established at present.
Journal ArticleDOI
Collagen Network of the Myocardium: Function, Structural Remodeling and Regulatory Mechanisms
TL;DR: A collagen network, composed largely of type I and III fibrillar collagens, is found in the extracellular space of the myocardium, which contains a proteolytic system, including collagenase.
Journal ArticleDOI
A physiological role for titin and nebulin in skeletal muscle
TL;DR: The ability of single skinned muscle cells to generate both passive tension in response to stretch and active tension in Response to calcium is greatly reduced after low doses of ionizing radiation, accompanied by axial misalignment of thick filaments.
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Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity
The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line.
The Giant Protein Titin: A Major Player in Myocardial Mechanics, Signaling, and Disease
Henk Granzier,Siegfried Labeit +1 more