Journal ArticleDOI
Pemphigus. S2 Guideline for diagnosis and treatment – guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV)
Michael Hertl,Hana Jedličková,Sarolta Kárpáti,Branka Marinović,Soner Uzun,Savaş Yayli,Daniel Mimouni,Luca Borradori,Claudio Feliciani,Demetris Ioannides,Pascal Joly,Cezary Kowalewski,Giovanna Zambruno,Detlef Zillikens,Marcel F. Jonkman +14 more
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TLDR
Pemphigus encompasses a group of life‐threatening autoimmune bullous diseases characterized by blisters and erosions of the mucous membranes and skin that was almost fatal before the era of immunosuppressive treatment.Abstract:
BACKGROUND
Pemphigus encompasses a group of life-threatening autoimmune bullous diseases characterized by blisters and erosions of the mucous membranes and skin. Before the era of immunosuppressive treatment, the prognosis of pemphigus was almost fatal. Due to its rarity, only few prospective controlled therapeutic trials are available.
OBJECTIVES
For this reason, a group of European dermatologists with a long-standing interest and expertise in basic and clinical pemphigus research has sought to define diagnostic and therapeutic guidelines for the management of patients with pemphigus.
RESULTS
This group identified the statements of major agreement or disagreement regarding the diagnostic and therapeutic management of pemphigus. The revised final version of the pemphigus guideline was finally passed on to the European Dermatology Forum (EDF) for a final consensus with the European Academy of Dermatology and Venereology (EADV) and the European Union of Medical Specialists (UEMS).read more
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First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial.
Pascal Joly,Maud Maho-Vaillant,Catherine Prost-Squarcioni,Vivien Hébert,Estelle Houivet,Sébastien Calbo,Frédérique Caillot,Marie-Laure Golinski,Bruno Labeille,Catherine Picard-Dahan,Carle Paul,Marie-Aleth Richard,Jean-David Bouaziz,Sophie Duvert-Lehembre,Philippe Bernard,Frédéric Caux,Marina Alexandre,Saskia Ingen-Housz-Oro,Pierre Vabres,Emmanuel Delaporte,Gaëlle Quéreux,Alain Dupuy,Sébastien Debarbieux,Martine Avenel-Audran,Michel D'Incan,Christophe Bedane,Nathalie Beneton,Denis Jullien,Nicolas Dupin,Laurent Misery,Laurent Machet,Marie Beylot-Barry,Olivier Dereure,Bruno Sassolas,Thomas Vermeulin,Jacques Benichou,P. Musette +36 more
TL;DR: Data from this trial suggest that first-line use of rituximab plus short-termprednisone for patients with pemphigus is more effective than using prednisone alone, with fewer adverse events.
Journal ArticleDOI
Diagnosis and management of pemphigus: Recommendations of an international panel of experts
Dedee F. Murrell,Sandra Pena,Sandra Pena,Pascal Joly,Branka Marinović,Takashi Hashimoto,Luis A. Diaz,Animesh A. Sinha,Aimee S. Payne,Maryam Daneshpazhooh,Rüdiger Eming,Marcel F. Jonkman,Daniel Mimouni,Luca Borradori,Soo Chan Kim,Jun Yamagami,Julia S. Lehman,Marwah A. Saleh,Donna A. Culton,Annette Czernik,John J. Zone,David P. Fivenson,Hideyuki Ujiie,Katarzyna Wozniak,Ayşe Akman-Karakaş,Philippe Bernard,Neil J. Korman,Frédéric Caux,Kossara Drenovska,Catherine Prost-Squarcioni,Snejina Vassileva,Ron J. Feldman,Adela R. Cardones,Johann W. Bauer,Dimitrios Ioannides,Hana Jedličková,Francis Palisson,Aikaterini Patsatsi,Soner Uzun,Savaş Yayli,Detlef Zillikens,Masayuki Amagai,Michael Hertl,Enno Schmidt,Valeria Aoki,Sergei A. Grando,Hiroshi Shimizu,Sharon Baum,Guiseppe Cianchini,Claudio Feliciani,Pilar Iranzo,José M. Mascaró,Cezary Kowalewski,Russell P. Hall,Richard Groves,Karen E. Harman,M. Peter Marinkovich,M. Peter Marinkovich,Emanual Michael Maverakis,Victoria P. Werth,Victoria P. Werth +60 more
TL;DR: Recommendations from a subsequent Delphi consensus to broaden the generalizability of recommendations includes intravenous CD20 inhibitors as a first line therapy option for moderate to severe pemphigus.
Journal Article
American College of Rheumatology 2010 Recommendations for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis
Rebecca G,Chad D +1 more
Journal ArticleDOI
Characterization of IgG4 anti-neurofascin 155 antibody-positive polyneuropathy
Hidenori Ogata,Ryo Yamasaki,Akio Hiwatashi,Nobuyuki Oka,Nobutoshi Kawamura,Dai Matsuse,Motoi Kuwahara,Hidekazu Suzuki,Susumu Kusunoki,Yuichi Fujimoto,Koji Ikezoe,Hitaru Kishida,Fumiaki Tanaka,Takuya Matsushita,Hiroyuki Murai,Jun Ichi Kira +15 more
TL;DR: To investigate anti‐neurofascin 155 (NF155) antibody‐positive chronic inflammatory demyelinating polyneuropathy (CIDP) and its role in promoting wound healing and down-regulation in mice with CIDP.
Journal ArticleDOI
British Association of Dermatologists' guidelines for the management of pemphigus vulgaris 2017.
Karen E. Harman,David Brown,L S Exton,Richard Groves,P.J. Hampton,M F Mohd Mustapa,Jane Setterfield,P D Yesudian +7 more
TL;DR: British Association of Dermatologists’ guidelines for the management of pemphigus vulgaris 2017* are published.
References
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Journal ArticleDOI
Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion
TL;DR: It is demonstrated that a novel epithelial cadherin is the target of autoantibodies in PV, and the deduced amino acid sequence of PVA was unique but showed significant homology with members of the cadher in family of Ca(2+)-dependent cell adhesion molecules.
Journal ArticleDOI
Recommendations for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis
Marc C. Hochberg,Mark J. Prashker,Maria Greenwald,Rancho Mirage,Marian T. Hannan,Nancy E Lane,Stephen M. Lindsey,Daniel J. Lovell,Elizabeth A. Tindall +8 more
TL;DR: Treatment with a bisphosphonate is recommended to prevent bone loss in all men and postmenopausal women in whom long-term glucocorticoid treatment at > or =5 mg/day is being initiated, as well as in men andPost menopausal women receiving long- term glucocORTicoids in whom the BMD T-score at either the lumbar spine or the hip is below normal.
Journal ArticleDOI
American College of Rheumatology 2010 recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis.
Jennifer M. Grossman,Rebecca Gordon,Veena K. Ranganath,Chad L. Deal,Liron Caplan,Weiling Chen,Jeffrey R. Curtis,Daniel E. Furst,Maureen McMahon,Nivedita M. Patkar,Elizabeth R. Volkmann,Kenneth G. Saag +11 more
TL;DR: Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology are intended to provide guidance for particular patterns of practice and not to dictate the care of a particular patient.
Journal ArticleDOI
Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis: 2001 Update: American College of Rheumatology Ad Hoc Committee on glucocorticoid-induced osteoporosis
Lenore M. Buckley,M. Greenwald,M. Hochberg,Nancy E Lane,S. Lindsey,Stephen A. Paget,Kenneth G. Saag,L. Simon +7 more
Journal ArticleDOI
Induction of Pemphigus in Neonatal Mice by Passive Transfer of IgG from Patients with the Disease
TL;DR: This study strongly supports the proposed role of pemphigus autoantibodies in the pathogenesis of p emphigu vulgaris in human beings and demonstrates that pemPHigus can be passively transferred to laboratory animals.
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