Journal ArticleDOI
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
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TLDR
A body of work supporting the conclusion that perioperative use of gabapentinoids reduces early postoperative pain and opioid use is described, which may inform a surgeon's or anesthesiologist’s optimization of perioperatively use of these drugs, including choice of agent, dose, timing, and duration of therapy.Abstract:
1215 November 2013 T gabapentinoids pregabalin and gabapentin are both indicated for the treatment of postherpetic neuralgia and as adjuvant therapy for seizure disorders. Pregabalin is additionally approved for the treatment of fibromyalgia and neuropathic pain associated with diabetes mellitus or spinal cord injury. There are now more than 100 clinical trials examining the use of gabapentin perioperatively to reduce postoperative pain and a smaller but growing number of clinical trials examining the efficacy of pregabalin. As a body of work, they support the conclusion that perioperative use of gabapentinoids reduces early postoperative pain and opioid use.1–3 This article describes how this body of work may inform a surgeon’s or anesthesiologist’s optimization of perioperative use of gabapentinoids, including choice of agent, dose, timing, and duration of therapy. In addition, we described the less clear data for and against gabapentinoid efficacy in preventing the emergence of chronic postsurgical pain. Mechanisms of Action, Pharmacokinetics, and Adverse Effects Although both of the gabapentinoids are structural analogs of γ-aminobutyric acid, neither has any activity at the γ-aminobutyric acid receptors (fig. 1). Instead, they bind to the α-2δ subunit of presynaptic P/Q-type voltage-gated calcium channels, modulating the traffic and function of these channels. This in turn is thought to modulate the subsequent release of excitatory neurotransmitters from activated nociceptors.4 By modulating calcium-induced release of glutamate from activated pain-transmitting neurons, these drugs may inhibit pain transmission and central sensitization (fig. 2). Alternatively, some evidence indicates that their antinociceptive mechanism may arise through activation of noradrenergic pain-inhibiting pathways in the spinal cord and brain.5 The principal differences between these two drugs arise not from different modes of action but rather from differing bioavailability. Although both drugs are absorbed by amino acid carriers, gabapentin absorption is limited to a relatively small part of the duodenum, whereas pregabalin is absorbed throughout the small intestine. Once the active transport of gabapentin in the duodenum is saturated, progressively higher levels of gabapentin ingestion yield progressively smaller increases in blood concentrations. Conceptually, this provides an upper border not only to efficacy but also to adverse effects. In contrast, pregabalin appears to be absorbed throughout the small intestines and demonstrates linear uptake without transporter saturation at therapeutic concentrations.6,7 Therefore, at least conceptually, pregabalin might demonstrate both increased efficacy and increased side effects in situations that require high doses. Both pregabalin and gabapentin exhibit minimal protein binding and are renally excreted without significant metabolism. Pharmacokinetic interactions are minimal, though gabapentin absorption can be significantly impaired by antacids, even when given up to 2 h after dosing. This should be considered in preoperative Copyright © 2013, the American Society of Anesthesiologists, Inc. Lippincott Williams & Wilkins. Anesthesiology 2013; 119:1215–21 * Clinical Instructor of Anesthesiology, † Research Assistant, ‡ Professor of Anesthesiology and Pain Medicine, § Assistant Professor of Anesthesiology and Pain Medicine, Department of Anesthesiology, Perioperative, and Pain Medicine, Division of Pain Medicine, Stanford University, Palo Alto, California.read more
Citations
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Journal ArticleDOI
Guidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS ® ) Society Recommendations.
Donald E. Low,William H. Allum,Giovanni de Manzoni,Lorenzo E. Ferri,Arul Immanuel,Madhan Kumar Kuppusamy,Simon Law,Mats Lindblad,Nick Maynard,Joseph M. Neal,C S Pramesh,Michael J. Scott,B. Mark Smithers,Valérie Addor,Olle Ljungqvist +14 more
TL;DR: The current ERAS society guidelines should be reviewed and applied in all centers looking to improve outcomes and quality associated with esophageal resection.
Guidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS((R))) Society Recommendations
Donald E. Low,William H. Allum,G De Manzoni,Lorenzo E. Ferri,Arul Immanuel,MadhanKumar Kuppusamy,Simon Law,Mats Lindblad,Nick Maynard,Joseph M. Neal,C.S. Pramesh,Michael J. Scott,B. M Smithers,Addor,Olle Ljungqvist +14 more
TL;DR: In this paper, a team of international experts in the surgical management of esophageal cancer was assembled and the existing literature was identified and reviewed prior to the production of the guidelines.
Journal ArticleDOI
Postoperative delirium: perioperative assessment, risk reduction, and management
Zhaosheng Jin,Jie Hu,Daqing Ma +2 more
TL;DR: It is proposed that risk assessment and perioperative risk reduction may be the most effective approaches in managing postoperative delirium.
Journal ArticleDOI
Mechanisms of the gabapentinoids and α2δ‐1 calcium channel subunit in neuropathic pain
Ryan Patel,Anthony H. Dickenson +1 more
TL;DR: The current understanding of the pathophysiological role of the α2δ‐1 subunit, the mechanisms of analgesic action of gabapentinoid drugs and implications for efficacy in the clinic are reviewed.
Journal ArticleDOI
Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: A Randomized Clinical Trial.
Jennifer M. Hah,Sean Mackey,Peter C. Schmidt,Rebecca McCue,Keith Humphreys,Jodie A. Trafton,Bradley Efron,Debra Clay,Yasamin Sharifzadeh,Gabriela Ruchelli,Stuart B. Goodman,James I. Huddleston,William J. Maloney,Frederick M. Dirbas,Joseph B. Shrager,John G. Costouros,Catherine Curtin,Ian Carroll +17 more
TL;DR: Perioperative administration of gabapentin had no effect on postoperative pain resolution, but it had a modest effect on promoting opioid cessation after surgery, which may be warranted to promote opioid cessation and prevent chronic opioid use.
References
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Journal ArticleDOI
Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial.
Asokumar Buvanendran,Jeffrey S. Kroin,Craig J. Della Valle,Maruti Kari,Mario Moric,Kenneth J. Tuman +5 more
TL;DR: Perioperative pregabalin administration reduces the incidence of chronic neuropathic pain after TKA, with less opioid consumption and better range of motion during the first 30 days of rehabilitation, however, in the doses tested, it is associated with a higher risk of early postoperative sedation and confusion.
Journal ArticleDOI
The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis.
Hance Clarke,Robert P. Bonin,Beverley A. Orser,Marina Englesakis,Duminda N. Wijeysundera,Joel Katz +5 more
TL;DR: The view that perioperative administration of gabapentin and pregabalin are effective in reducing the incidence of CPSP is supported.
Journal ArticleDOI
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
TL;DR: Investigation of the analgesic efficacy of mexiletine and gabapentin on acute and chronic pain associated with cancer breast surgery in 75 patients found pain at rest and after movement was reduced by both drugs on the third postoperative day.
Journal ArticleDOI
Efficacy of pregabalin in acute postoperative pain: a meta-analysis
Jiaqiang Zhang,K.-Y. Ho,Y. Wang +2 more
TL;DR: Perioperative pregabalin administration reduced opioid consumption and opioid-related adverse effects after surgery, and the risk of visual disturbance was greater.
Journal ArticleDOI
The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis.
TL;DR: Perioperative oral gabapentin is a useful adjunct for the management of postoperative pain that provides analgesia through a different mechanism than opioids and other analgesic agents and would make a reasonable addition to a multimodal analgesic treatment plan.
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