Journal ArticleDOI
Permeation of hydrophilic solutes through mitochondrial outer membranes: review on mitochondrial porins
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This article is published in Biochimica et Biophysica Acta.The article was published on 1994-06-29. It has received 424 citations till now. The article focuses on the topics: Inner mitochondrial membrane & Membrane.read more
Citations
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Fatty acid import into mitochondria.
Janos Kerner,Charles L. Hoppel +1 more
TL;DR: It is proposed that contact sites between the outer and inner mitochondrial membranes form a microenvironment which facilitates the carnitine transport system and includes the long-chain acyl-CoA synthetase and porin as components.
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VDAC, a multi-functional mitochondrial protein regulating cell life and death.
TL;DR: What is known about the VDAC channel in terms of its structure, relevance to ATP rationing, Ca(2+) homeostasis, protection against oxidative stress, regulation of apoptosis, involvement in several diseases and its role in the action of different drugs is reviewed.
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Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2
Paul H. Schlesinger,Atan Gross,Xiao Ming Yin,Kazuhito Yamamoto,Mitsuyoshi Saito,Gabriel Waksman,Stanley J. Korsmeyer,Stanley J. Korsmeyer +7 more
TL;DR: BAX and BCL-2 each form channels in artificial membranes that have distinct characteristics including ion selectivity, conductance, voltage dependence, and rectification, and one role of these molecules may include pore activity at selected membrane sites.
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Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes
TL;DR: Investigation of the ability of mitochondria to modulate store-operated or “capacitative” Ca2+ entry in Jurkat leukemic T cells and human T lymphocytes shows that mitochondria play an active role in modulating the rate of capacitative Ca2+, and rhod-2 labels mitochondria in T cells.
References
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A simple method for displaying the hydropathic character of a protein
Jack Kyte,Russell F. Doolittle +1 more
TL;DR: A computer program that progressively evaluates the hydrophilicity and hydrophobicity of a protein along its amino acid sequence has been devised and its simplicity and its graphic nature make it a very useful tool for the evaluation of protein structures.
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An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study.
TL;DR: Experiments with tritiated NADH are described which demonstrate that this "external" pathway of NADH oxidation resembles stereochemically the NADH-cytochrome c reductase system of liver microsomes, and differs from the respiratory chain-linked NADH dehydrogenase.
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Mechanisms by which mitochondria transport calcium.
Thomas E. Gunter,D. R. Pfeiffer +1 more
TL;DR: It has been suggested that the permeability transition and its reversal may also function as a mitochondrial Ca2+ efflux mechanism under some conditions.
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Crystal structures explain functional properties of two E. coli porins
S. W. Cowan,Tilman Schirmer,Gabriele Rummel,Matthias Steiert,Robin Ghosh,Richard A. Pauptit,Johan N. Jansonius,Jurg P. Rosenbusch +7 more
TL;DR: The crystal structures of matrix porin and phosphoporin both reveal trimers of identical subunits, each subunit consisting of a 16-stranded anti-parallel β-barrel containing a pore.
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Reconstitution of Cell Membrane Structure in vitro and its Transformation into an Excitable System
TL;DR: By forming such a membrane between two compartments filled with saline its transverse electrical properties can be measured, and controlled chemical investigations can be undertaken.