Journal ArticleDOI
Pharmacological tools for the development of traditional Chinese medicine
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TLDR
In the present review, three models for the pharmacological study of TCM are considered: (i) chemistry-focused study; (ii) target-directed study; and (iii) systems-biology-based study.About:
This article is published in Trends in Pharmacological Sciences.The article was published on 2013-11-01. It has received 66 citations till now.read more
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Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective.
TL;DR: The methodology of network pharmacology, including network construction, network analysis and network verification, is summarized, expecting to provide new strategy and thinking on study for CM formula.
Journal ArticleDOI
Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction
Shan-Shan Zhou,Jun Xu,He Zhu,Jie Wu,Jin-Di Xu,Ru Yan,Xiu-Yang Li,Xiu-Yang Li,Huan-Huan Liu,Huan-Huan Liu,Su-Min Duan,Zhuo Wang,Hubiao Chen,Hong Shen,Song-Lin Li,Song-Lin Li +15 more
TL;DR: Results indicated that ginseng polysaccharides improved intestinal metabolism and absorption of certain ginsenosides, meanwhile reinstated the perturbed holistic gut microbiota, and particularly enhanced the growth of Lactobacillus spp.
Journal ArticleDOI
Natural Products as a Source for Antifibrosis Therapy
TL;DR: Natural products can target these mediators and inhibit chronic inflammation, myofibroblast activation, epithelial-mesenchymal transition, and extracellular matrix accumulation to alleviate fibrosis and provide new strategies to find antifibrotic drugs.
Journal ArticleDOI
An integrated chinmedomics strategy for discovery of effective constituents from traditional herbal medicine
Xijun Wang,Aihua Zhang,Xiaohang Zhou,Qi Liu,Yang Nan,Yu Guan,Ling Kong,Ying Han,Hui Sun,Guangli Yan +9 more
TL;DR: The study showed that integrated chinmedomics is a powerful strategy for discovery and screening of effective constituents from herbal medicines and related to aldosterone-regulated sodium reabsorption and adrenergic signaling pathways.
Journal ArticleDOI
Novel applications of mass spectrometry-based metabolomics in herbal medicines and its active ingredients: Current evidence.
TL;DR: The value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, and to enhance their biomedical value in biomedicine is highlighted.
References
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Trends in Alternative Medicine Use in the United States, 1990-1997 Results of a Follow-up National Survey
David Eisenberg,Roger B. Davis,Susan L. Ettner,Scott Appel,Sonja Wilkey,Maria I. Van Rompay,Ronald C. Kessler +6 more
TL;DR: Alternative medicine use and expenditures increased substantially between 1990 and 1997, attributable primarily to an increase in the proportion of the population seeking alternative therapies, rather than increased visits per patient.
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Natural Products as Sources of New Drugs over the Last 25 Years
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003 and is able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame.
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Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of the three prior reviews and adds a new designation, "natural product botanical" or "NB", to cover those botanical "defined mixtures" that have now been recognized as drug entities by the FDA and similar organizations.
Journal ArticleDOI
Network pharmacology: the next paradigm in drug discovery.
TL;DR: A new appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development--efficacy and toxicity.
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Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.
Wei-Jia Kong,Jing Wei,Parveen Abidi,Meihong Lin,Satoru Inaba,Cong Li,Yanling Wang,Zi-Zheng Wang,Shuyi Si,Huai-Ning Pan,Shukui Wang,Jingdan Wu,Yue Wang,Zhuorong Li,Jingwen Liu,Jian-Dong Jiang,Jian-Dong Jiang +16 more
TL;DR: Findings show berberine (BBR) as a new hypolipidemic drug with a mechanism of action different from that of statin drugs.