Journal ArticleDOI
Piper nigrum and piperine: an update
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TLDR
In this review, the chemical constituents, biological activities, effects of processing, and future potential of black pepper and piperine have been discussed thoroughly.Abstract:
Black pepper (Piper nigrum L.) is a very widely used spice, known for its pungent constituent piperine. However, in addition to its culinary uses, pepper has important medicinal and preservative properties, and, more recently, piperine has been shown to have fundamental effects on p-glycoprotein and many enzyme systems, leading to biotransformative effects including chemoprevention, detoxification, and enhancement of the absorption and bioavailability of herbal and conventional drugs. Based on modern cell, animal, and human studies, piperine has been found to have immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties. In this review, the chemical constituents, biological activities, effects of processing, and future potential of black pepper and piperine have been discussed thoroughly.read more
Citations
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Journal ArticleDOI
Piperine—The Bioactive Compound of Black Pepper: From Isolation to Medicinal Formulations
TL;DR: A thorough review on conventional and advanced separation techniques for the extraction of piperine from pepper is presented and an outline of the most significant conditions to improve the extraction yield is provided and discussed.
Journal ArticleDOI
Chronic diseases, inflammation, and spices: how are they linked?
Ajaikumar B. Kunnumakkara,Bethsebie Lalduhsaki Sailo,Kishore Banik,Choudhary Harsha,Sahdeo Prasad,Subash C. Gupta,Alok C. Bharti,Bharat B. Aggarwal +7 more
TL;DR: The potential of various dietary agents such as spices and its components in the suppression of inflammatory pathways and their roles in the prevention and therapy of cancer and other chronic diseases are discussed.
Journal ArticleDOI
Natural alkaloids: basic aspects, biological roles, and future perspectives.
TL;DR: This paper focuses on the naturally-derived alkaloids such as berberine, matrine, piperine, fritillarine, and rhynchophylline and summarizes the action mechanisms of these compounds.
Journal ArticleDOI
Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress
TL;DR: Cell cycle arrest and endoplasmic reticulum stress‐associated apoptosis following piperine treatment of HT‐29 cells provides the first evidence that p Piperine may be useful in the treatment of colon cancer.
Journal ArticleDOI
Piperine inhibits the growth and motility of triple-negative breast cancer cells
Anna L. Greenshields,Carolyn D. Doucette,Kimberly M. Sutton,Laurence Madera,Henry Annan,Paul B. Yaffe,Allison F. Knickle,Zhongmin Dong,David W. Hoskin,David W. Hoskin +9 more
TL;DR: It is suggested that piperine may be useful in the treatment of TNBC because of its inhibition of survival-promoting Akt activation in TNBC cells and caused caspase-dependent apoptosis via the mitochondrial pathway.
References
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Journal ArticleDOI
Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects
TL;DR: Piperine has been demonstrated in in vitro studies to protect against oxidative damage by inhibiting or quenching free radicals and reactive oxygen species, and to enhance the bioavailability of a number of therapeutic drugs as well as phytochemicals by this very property.
Journal ArticleDOI
Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes
A C Reddy,Belur R. Lokesh +1 more
TL;DR: The inhibition of lipid peroxidation by curcumin and eugenol was reversed by adding high concentrations of Fe2+.
Journal ArticleDOI
Immunomodulatory and antitumor activity of Piper longum Linn. and piperine.
E.S Sunila,G Kuttan +1 more
TL;DR: Administration of alcoholic extract of Piper longum as well as piperine could inhibit the solid tumor development in mice induced with DLA cells and increase the life span of mice bearing Ehrlich ascites carcinoma tumor to 37.3 and 58.8%, respectively.
Journal ArticleDOI
Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats
TL;DR: Positive influences on the pancreatic digestive enzymes exerted by a good number of spices consumed in diet could be a factor contributing to the well recognised digestive stimulant action of spices.
Journal Article
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.
C.K. Atal,R K Dubey,J. Singh +2 more
TL;DR: It is demonstrated that piperine is a nonspecific inhibitor of drug metabolism which shows little discrimination between different cytochrome P-450 forms.
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