Journal ArticleDOI
Pituitary hormones modulate cell–cell interactions between thymocytes and thymic epithelial cells
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The data suggest that the in vitro changes in thymocyte/thymic epithelial cell interactions induced by pituitary hormones are partially mediated by the enhancement of extracellular matrix ligands and receptors.About:
This article is published in Journal of Neuroimmunology.The article was published on 1997-06-01. It has received 80 citations till now. The article focuses on the topics: Thymocyte & Cell signaling.read more
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The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency.
TL;DR: New experimental evidence from analysis of lymphocyte development and function in mice with genetic defects in expression of these hormones or their receptors that calls into question the presumed role played by some ofThese hormones and reveals unexpected effects of others are addressed.
Journal ArticleDOI
Neuroendocrine Control of Thymus Physiology
Wilson Savino,Mireille Dardenne +1 more
TL;DR: Data is summarized showing that thymus physiology is pleiotropically influenced by hormones and neuropeptides, which modulate the expression of major histocompatibility complex gene products by microenvironmental cells and the extracellular matrix-mediated interactions, leading to enhanced thymocyte adhesion to thymic epithelial cells.
Journal ArticleDOI
Human conditions of insulin-like growth factor-I (IGF-I) deficiency
TL;DR: The aim of this review is to summarize the increasing list of roles of IGF-I, both in physiological and pathological conditions, underlying that its potential therapeutical options seem to be limited to those proven states of local or systemic IGF- I deficiency as a replacement treatment, rather than increasing its level upper the normal range.
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Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases?
TL;DR: Recognizing the broader role of IGF-IR in regulating both normal and pathological immune responses may offer important opportunities for therapeutic intervention in several allied diseases that have proven particularly difficult to treat.
Journal ArticleDOI
Prolactin modulates the naive B cell repertoire
TL;DR: Prolactin effects on anti-DNA B cells in nonspontaneously autoimmune female BALB/c mice transgenic for the heavy chain of an anti- DNA antibody suggested that prolactin has immunomodulatory functions.
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Journal ArticleDOI
Cellular Interactions in Thymocyte Development
TL;DR: Alongside the functional roles of stromal cells, considerable progress is being made in unraveling the nature of the signaling pathways involved in T cell development, and identification of the pre-T cell receptor and associated signaling molecules marks an important advance.
Journal ArticleDOI
The thymic microenvironment
Richard L. Boyd,C L Tucek,Dale I. Godfrey,D J Izon,Trevor J. Wilson,Natalie J. Davidson,Andrew G. D. Bean,Heather M. Ladyman,Mary A. Ritter,Patrice Hugo +9 more
TL;DR: A detailed overview of the basic thymic components is provided, backed up by an extensive bibliography and full colour poster, followed by an examination of the mutual interdependence ofThymic stroma and thymocyte.
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Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization.
TL;DR: A new cellular component of normal mouse thymuses is described, which is isolated by fractionated trypsin dissociation of minced thymus tissue followed by repeated unit gravity sedimentation and is the basis of a hypothesis that postulates that an intraepithelial differentiation cycle is one essential step in, intrathymic T lymphocyte generation.
Journal ArticleDOI
T-cell differentiation is influenced by thymic microenvironments.
TL;DR: Insight is provided into lympho-stromal interaction and the role of thymic microenvironments in positive and negative selection of the T-cell repertoire, and the potential influence of T cells on the development ofThymicmicroenvironments is discussed.
Journal Article
Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens
TL;DR: TE cell-thymocyte binding is blocked by antibodies to theCD-2 (T11) antigen on thymocytes and by an antibody to the LFA-3 antigen on TE cells, suggesting that a natural ligand for T cell activation via the CD-2 molecule is present on human thymic epithelial cells.