Journal ArticleDOI
Plasma membrane Ca2+-ATPase isoforms in frog crista ampullaris: identification of PMCA1 and PMCA2 specific splice variants.
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TLDR
The identity and distribution of PMCA isoforms in frog crista ampullaris were determined: it was shown that PMCA1, PMCA2 and PMCA3 are expressed, while PMCA4 appears to be negligible.About:
This article is published in Hearing Research.The article was published on 2007-06-01. It has received 2 citations till now. The article focuses on the topics: Crista ampullaris & Hair cell.read more
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Journal ArticleDOI
Probing the Xenopus laevis inner ear transcriptome for biological function.
TL;DR: The use of informatics approaches to impart biologically relevant information to the Xenopus inner ear transcriptome, thereby addressing the impediment imposed by insufficient gene annotation, heighten the relevance of Xenopus as a model organism for genetic investigations of inner ear organogenesis, morphogenesis, and regeneration.
Book ChapterDOI
Hair Cells and Their Synapses
TL;DR: This review discusses the most recent findings from the morphological to the molecular to the functional specializations of the hair cell ribbon synapse that allow for these unique synaptic properties.
References
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Journal ArticleDOI
Congenital Deafness and Sinoatrial Node Dysfunction in Mice Lacking Class D L-Type Ca2+ Channels
Josef Platzer,Jutta Engel,Anneliese Schrott-Fischer,K Stephan,Sergio Bova,Howard Y. Chen,Hui Zheng,Jörg Striessnig +7 more
TL;DR: It is concluded that alpha1D can form LTCCs with negative activation thresholds essential for normal auditory function and control of cardiac pacemaker activity.
Journal ArticleDOI
Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cells
TL;DR: The close association among Ca2+ channels, Ca2(+)-activated K- channels, and synaptic active zones is necessary both for the rapid activation of K+ currents required in electrical resonance and for the transmission at afferent synapses of information about the phases of high-frequency stimuli.
Journal ArticleDOI
Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.
TL;DR: The identification of mice carrying PMCA mutations that lead to diseases such as hearing loss and ataxia, as well as the corresponding phenotypes of genetically engineered PMCA "knockout" mice further support the concept of specific, nonredundant roles for each Ca( 2+) pump isoform in cellular Ca(2+) regulation.
Journal ArticleDOI
A defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1C.
Elisabeth Verpy,Michel Leibovici,Ingrid Zwaenepoel,Xue Zhong Liu,Andreas Gal,Nabiha Salem,Ahmad M. Mansour,Stéphane Blanchard,Ichiro Kobayashi,Bronya J.B. Keats,Rima Slim,Christine Petit +11 more
TL;DR: A gene underlying USH1C is identified, encoding a PDZ-domain–containing protein, harmonin, in a subtracted mouse cDNA library derived from inner ear sensory areas, and it is proposed that Ush1C also underlies the DFNB18 form of isolated deafness.
Journal ArticleDOI
Mechanisms of hair cell tuning.
Robert Fettiplace,Paul A. Fuchs +1 more
TL;DR: Mechanosensory hair cells of the vertebrate inner ear contribute to acoustic tuning through feedback processes involving voltage-gated channels in the basolateral membrane and mechanotransduction channel in the apical hair bundle.